matrix presented The putative structure of the naturally occurring clerodane diterpenoid (±)-sacacarin has been prepared in only 10 steps, six of which are C-C bond-forming steps, in a chemo-, regio-, and diastereoselective manner. The key part of the synthesis is the double annulation (double Michael, Pinner, and Dieckmann reaction) of a tethered carbon diacid and 3-butyn-2-one. A corrected structure for sacacarin is proposed, and the structure is proven by synthesis.
|Number of pages||4|
|State||Published - Dec 13 2001|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry