Signal transduction and neurosurvival in experimental models of brain injury

T. L. Butler, C. A. Kassed, K. R. Pennypacker

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Brain injury and neurodegenerative disease are linked by their primary pathological consequence - death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed.

Original languageEnglish
Pages (from-to)339-351
Number of pages13
JournalBrain Research Bulletin
Issue number5
StatePublished - Jan 30 2003


  • Animal model
  • AP-1
  • Growth factor
  • Neuron
  • NF-κB
  • Signaling pathways

ASJC Scopus subject areas

  • Neuroscience (all)


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