Abstract
Brain injury and neurodegenerative disease are linked by their primary pathological consequence - death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed.
Original language | English |
---|---|
Pages (from-to) | 339-351 |
Number of pages | 13 |
Journal | Brain Research Bulletin |
Volume | 59 |
Issue number | 5 |
DOIs | |
State | Published - Jan 30 2003 |
Keywords
- Animal model
- AP-1
- Growth factor
- Neuron
- NF-κB
- Signaling pathways
ASJC Scopus subject areas
- Neuroscience (all)