Signal transduction and neurosurvival in experimental models of brain injury

T. L. Butler; C. A. Kassed; K. R. Pennypacker

doi:10.1016/S0361-9230(02)00926-7

Signal transduction and neurosurvival in experimental models of brain injury

T. L. Butler, C. A. Kassed, K. R. Pennypacker

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Brain injury and neurodegenerative disease are linked by their primary pathological consequence - death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed.

Original language	English
Pages (from-to)	339-351
Number of pages	13
Journal	Brain Research Bulletin
Volume	59
Issue number	5
DOIs	https://doi.org/10.1016/S0361-9230(02)00926-7
State	Published - Jan 30 2003

Keywords

AP-1
Animal model
Growth factor
NF-κB
Neuron
Signaling pathways

ASJC Scopus subject areas

General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0361-9230(02)00926-7

Cite this

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abstract = "Brain injury and neurodegenerative disease are linked by their primary pathological consequence - death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed.",

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AU - Butler, T. L.

AU - Kassed, C. A.

AU - Pennypacker, K. R.

PY - 2003/1/30

Y1 - 2003/1/30

N2 - Brain injury and neurodegenerative disease are linked by their primary pathological consequence - death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed.

AB - Brain injury and neurodegenerative disease are linked by their primary pathological consequence - death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed.

KW - AP-1

KW - Animal model

KW - Growth factor

KW - NF-κB

KW - Neuron

KW - Signaling pathways

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U2 - 10.1016/S0361-9230(02)00926-7

DO - 10.1016/S0361-9230(02)00926-7

M3 - Review article

C2 - 12507684

AN - SCOPUS:0037472348

SN - 0361-9230

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SP - 339

EP - 351

JO - Brain Research Bulletin

JF - Brain Research Bulletin

IS - 5

ER -

Signal transduction and neurosurvival in experimental models of brain injury

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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