Silent Orthohantavirus Circulation Among Humans and Small Mammals from Central Minas Gerais, Brazil

Carolina Dourado Amaral; Galileu Barbosa Costa; William Marciel de Souza; Pedro Augusto Alves; Iara Apolinário Borges; Aline Lavado Tolardo; Marília Farignoli Romeiro; Betânia Paiva Drumond; Jônatas Santos Abrahão; Erna Geessien Kroon; Adriano Pereira Paglia; Luiz Tadeu Moraes Figueiredo; Giliane de Souza Trindade

doi:10.1007/s10393-018-1353-2

Silent Orthohantavirus Circulation Among Humans and Small Mammals from Central Minas Gerais, Brazil

Carolina Dourado Amaral, Galileu Barbosa Costa, William Marciel de Souza, Pedro Augusto Alves, Iara Apolinário Borges, Aline Lavado Tolardo, Marília Farignoli Romeiro, Betânia Paiva Drumond, Jônatas Santos Abrahão, Erna Geessien Kroon, Adriano Pereira Paglia, Luiz Tadeu Moraes Figueiredo, Giliane de Souza Trindade

Microbiology, Immunology, and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

New World orthohantaviruses are emerging RNA viruses that cause hantavirus cardiopulmonary syndrome (HCPS). These viruses are a burden to public health around the world with a lethality rate of around 60%. In South America, rodents of Sigmodontinae subfamily are the main reservoirs of orthohantaviruses. We described a serosurvey for orthohantaviruses circulation in an apparently healthy human population and small mammals from rural areas in Central Minas Gerais State, Brazil. A total of 240 individuals and 50 small mammals (26 rodents belonging to 10 different species and 24 marsupials from 4 different species) were sampled during 2012–2013. The seroprevalence rates of IgG/IgM antibodies in humans were 7.1 and 1.6%, respectively. Only one rodent, an Oligoryzomys nigripes captured in peridomestic area, tested positive for IgG antibodies and viral RNA. Our findings suggest a silent circulation of orthohantaviruses in a region of intensive agriculture production. The detection of seropositive humans in an area with a lack of previous HCPS reports highlights potential oligosymptomatic cases and the need for surveillance strategies that could reduce the risk of future outbreaks.

Original language	English
Pages (from-to)	577-589
Number of pages	13
Journal	EcoHealth
Volume	15
Issue number	3
DOIs	https://doi.org/10.1007/s10393-018-1353-2
State	Published - Sep 1 2018

Bibliographical note

Publisher Copyright:
© 2018, EcoHealth Alliance.

Funding

We are thankful to colleagues from the Laboratório de Vírus (ICB-UFMG) and Centro de Pesquisa em Virologia, Faculdade de Medicina de Ribeirão Preto, for their excellent technical support. Financial support was provided by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenac¸ão de Aperfeic¸oamento de Pessoal de Nível Superior (CAPES), Fundac¸ão de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), and Pró-Reitoria de Pesquisa/UFMG (PRPq). J.S. Abrahão, E.G. Kroon, A. Paglia, L.T. Figueiredo, and G.S. Trindade are researchers from CNPq. We are thankful to colleagues from the Laboratório de Vírus (ICB-UFMG) and Centro de Pesquisa em Virologia, Faculdade de Medicina de Ribeirão Preto, for their excellent technical support. Financial support was provided by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), and Pró-Reitoria de Pesquisa/UFMG (PRPq). J.S. Abrahão, E.G. Kroon, A. Paglia, L.T. Figueiredo, and G.S. Trindade are researchers from CNPq.

Funders	Funder number
Centro de Pesquisa em Virologia
ICB-UFMG
Laboratório de Vírus
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundação de Amparo à Pesquisa do Estado de Minas Gerais
Universidade Federal de Minas Gerais
Pro-Reitoria de Pesquisa, Universidade de São Paulo

Keywords

Disease ecology
Ecoepidemiology
Juquitiba virus
Orthohantavirus
Rural population
Serosurvey
Small mammals

ASJC Scopus subject areas

Ecology
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10393-018-1353-2

Cite this

Amaral, C. D., Costa, G. B., de Souza, W. M., Alves, P. A., Borges, I. A., Tolardo, A. L., Romeiro, M. F., Drumond, B. P., Abrahão, J. S., Kroon, E. G., Paglia, A. P., Figueiredo, L. T. M., & de Souza Trindade, G. (2018). Silent Orthohantavirus Circulation Among Humans and Small Mammals from Central Minas Gerais, Brazil. EcoHealth, 15(3), 577-589. https://doi.org/10.1007/s10393-018-1353-2

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abstract = "New World orthohantaviruses are emerging RNA viruses that cause hantavirus cardiopulmonary syndrome (HCPS). These viruses are a burden to public health around the world with a lethality rate of around 60\%. In South America, rodents of Sigmodontinae subfamily are the main reservoirs of orthohantaviruses. We described a serosurvey for orthohantaviruses circulation in an apparently healthy human population and small mammals from rural areas in Central Minas Gerais State, Brazil. A total of 240 individuals and 50 small mammals (26 rodents belonging to 10 different species and 24 marsupials from 4 different species) were sampled during 2012–2013. The seroprevalence rates of IgG/IgM antibodies in humans were 7.1 and 1.6\%, respectively. Only one rodent, an Oligoryzomys nigripes captured in peridomestic area, tested positive for IgG antibodies and viral RNA. Our findings suggest a silent circulation of orthohantaviruses in a region of intensive agriculture production. The detection of seropositive humans in an area with a lack of previous HCPS reports highlights potential oligosymptomatic cases and the need for surveillance strategies that could reduce the risk of future outbreaks.",

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doi = "10.1007/s10393-018-1353-2",

language = "English",

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AU - Amaral, Carolina Dourado

AU - Costa, Galileu Barbosa

AU - de Souza, William Marciel

AU - Alves, Pedro Augusto

AU - Borges, Iara Apolinário

AU - Tolardo, Aline Lavado

AU - Romeiro, Marília Farignoli

AU - Drumond, Betânia Paiva

AU - Abrahão, Jônatas Santos

AU - Kroon, Erna Geessien

AU - Paglia, Adriano Pereira

AU - Figueiredo, Luiz Tadeu Moraes

AU - de Souza Trindade, Giliane

PY - 2018/9/1

Y1 - 2018/9/1

N2 - New World orthohantaviruses are emerging RNA viruses that cause hantavirus cardiopulmonary syndrome (HCPS). These viruses are a burden to public health around the world with a lethality rate of around 60%. In South America, rodents of Sigmodontinae subfamily are the main reservoirs of orthohantaviruses. We described a serosurvey for orthohantaviruses circulation in an apparently healthy human population and small mammals from rural areas in Central Minas Gerais State, Brazil. A total of 240 individuals and 50 small mammals (26 rodents belonging to 10 different species and 24 marsupials from 4 different species) were sampled during 2012–2013. The seroprevalence rates of IgG/IgM antibodies in humans were 7.1 and 1.6%, respectively. Only one rodent, an Oligoryzomys nigripes captured in peridomestic area, tested positive for IgG antibodies and viral RNA. Our findings suggest a silent circulation of orthohantaviruses in a region of intensive agriculture production. The detection of seropositive humans in an area with a lack of previous HCPS reports highlights potential oligosymptomatic cases and the need for surveillance strategies that could reduce the risk of future outbreaks.

AB - New World orthohantaviruses are emerging RNA viruses that cause hantavirus cardiopulmonary syndrome (HCPS). These viruses are a burden to public health around the world with a lethality rate of around 60%. In South America, rodents of Sigmodontinae subfamily are the main reservoirs of orthohantaviruses. We described a serosurvey for orthohantaviruses circulation in an apparently healthy human population and small mammals from rural areas in Central Minas Gerais State, Brazil. A total of 240 individuals and 50 small mammals (26 rodents belonging to 10 different species and 24 marsupials from 4 different species) were sampled during 2012–2013. The seroprevalence rates of IgG/IgM antibodies in humans were 7.1 and 1.6%, respectively. Only one rodent, an Oligoryzomys nigripes captured in peridomestic area, tested positive for IgG antibodies and viral RNA. Our findings suggest a silent circulation of orthohantaviruses in a region of intensive agriculture production. The detection of seropositive humans in an area with a lack of previous HCPS reports highlights potential oligosymptomatic cases and the need for surveillance strategies that could reduce the risk of future outbreaks.

KW - Disease ecology

KW - Ecoepidemiology

KW - Juquitiba virus

KW - Orthohantavirus

KW - Rural population

KW - Serosurvey

KW - Small mammals

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JO - EcoHealth

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ER -

Silent Orthohantavirus Circulation Among Humans and Small Mammals from Central Minas Gerais, Brazil

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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