Abstract
Roberts et al. have provided an insightful counterpoint to our review article on the utility of the synergist ablation model. The purpose of this review is to provide some further dialogue regarding the strengths and weaknesses of the synergist ablation model. Specifically, we highlight that the robustness of the model overshadows surgical limitations. We also compare the transcriptomic responses to synergist ablation in mice and resistance exercise in humans to identify common pathways. We conclude that “cell growth is cell growth” and that the mechanisms available to cells to accumulate biomass and increase in size are similar across cell types and independent of the rate of growth.
| Original language | English |
|---|---|
| Pages (from-to) | C614-C618 |
| Journal | American Journal of Physiology - Cell Physiology |
| Volume | 327 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 2024 |
Bibliographical note
Publisher Copyright:Copyright © 2024 The Authors Licensed under Creative Commons Attribution CC-BY 4.0.
Funding
This article was supported by the National Institute on Aging, National Institutes of Health; Grant/Award Number R01AG069909 (to J.J.M.) and R01AG080047 (to K.A.M.). This work was also supported by the Swedish Research Council (2022-01392) the Swedish Research Council for Sport Science (2022/10, 2023/09) to (F.v.W.).
| Funders | Funder number |
|---|---|
| National Institute on Aging | |
| National Institutes of Health (NIH) | R01AG069909, R01AG080047 |
| Centrum för idrottsforskning | 2023/09, 2022/10 |
| Vetenskapsrådet | 2022-01392 |
Keywords
- hypertrophy
- muscle
- resistance training
- synergist ablation
ASJC Scopus subject areas
- Physiology
- Cell Biology