Skeletal Muscle Nrf2 Contributes to Exercise-Evoked Systemic Antioxidant Defense Via Extracellular Vesicular Communication

Lie Gao, Han Jun Wang, Changhai Tian, Irving H. Zucker

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

This review explores the hypothesis that the repetitive contraction-relaxation that occurs during chronic exercise activates skeletal myocyte nuclear factor erythroid-derived 2-like 2 (Nrf2) to upregulate antioxidant enzymes. These proteins are secreted into the circulation within extracellular vesicles and taken up by remote cells, thus providing remote organs with cytoprotection against subsequent oxidative stress.

Original languageEnglish
Pages (from-to)213-222
Number of pages10
JournalExercise and Sport Sciences Reviews
Volume49
Issue number3
DOIs
StatePublished - 2021

Bibliographical note

Funding Information:
We thank Ms Tara L. Rudebush and Ms Li Yu for their expert technical assistance. We appreciate the professional service of Mass Spectrometry & Proteomics Core, Bioinformatics and Systems Biology Core, Flow Cytometry research Core, Nanomaterials Characterization Facility, and Electron Microscopy Facility of the University of Nebraska Medical Center (UNMC). The results presented here were supported, in part, by the National Institutes of Health grant P01 HL62222 (I.H.Z.) and the UNMC Frances E. Lageschulte and Evelyn B. Weese New Frontiers in Medical Research Fund (L.G.).

Publisher Copyright:
© Lippincott Williams & Wilkins.

Keywords

  • Nrf2
  • antioxidants
  • cardiac protection
  • exosomes
  • extracellular vesicles

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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