Sleep disturbance in pediatric intracranial hypertension

Alexandra B. Kornbluh, Katherine Thompson, Gada McMahen, David L. Rogers, Catherine O. Jordan, Shawn C. Aylward, Lenora M. Lehwald

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Study Objectives: There is a well-established association between headache disorders and sleep disturbances in children, but it is unknown whether sleep disturbance plays a role in pediatric intracranial hypertension. The objective of this study was to examine sleep issues related to pediatric intracranial hypertension. Methods: Patients with intracranial hypertension in the Pediatric Intracranial Hypertension Clinic were recruited between July 2017 and September 2018. Demographic data were collected fromthe electronicmedical record in addition to patient and parent completed questionnaires. Information on sleep behaviors was gathered using the Children's Sleep Habits Questionnaire, and control data were obtained from patient siblings. Statistical analyses were performed using paired t tests or two-sample t tests, as appropriate. Results: Sixty-two pairs of patients and matched sibling controls were compared. We found a statistically significant difference in total sleep disturbance score (control mean, 44.3; patientmean, 48.1; n = 33 pairs, t = -2.2, P =.035), as well as subscale scores of sleep onset delay (control mean, 1.4; patient mean, 1.7; n = 52 pairs, t = -2.53, P =.014), parasomnias (control mean, 8.5; patient mean, 9.5; n = 42 pairs, t = -2.59, P =.013), and sleep-disordered breathing (control mean, 3.1; patient mean, 3.4; n = 44 pairs, t = -2.61, P =.013). No difference was found in bedtime resistance, sleep duration, sleep anxiety, night awakenings, and daytime sleepiness subscales. Furthermore, no difference was found in total sleep disturbance score between patient subsets, including primary vs secondary intracranial hypertension, body mass index, pubertal status, presence of headaches, or intracranial hypertension treatment. Conclusions: This observational study suggests that pediatric intracranial hypertension is associated with a modest increase in sleep disturbances.

Original languageEnglish
Pages (from-to)1099-1105
Number of pages7
JournalJournal of Clinical Sleep Medicine
Volume16
Issue number7
DOIs
StatePublished - Jul 15 2020

Bibliographical note

Publisher Copyright:
© 2020 American Academy of Sleep Medicine. All rights reserved.

Keywords

  • Intracranial hypertension
  • Pediatric neurology
  • Pseudotumor cerebri
  • Sleep

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

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