Sleep Quality and Cognitive Function in Type 1 Diabetes: Findings from the Study of Longevity in Diabetes (SOLID)

Paola Gilsanz, Mary E. Lacy, Michal Schnaider Beeri, Andrew J. Karter, Chloe W. Eng, Rachel A. Whitmer

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Study Objective:The objective was to examine the association between sleep quality and global and domain-specific cognitive function among older individuals with type 1 diabetes (T1D).Methods:We evaluated 695 individuals with T1D aged 60 years or above who participated in the baseline assessment of the Study of Longevity in Diabetes (SOLID), which captured subjective sleep quality (Pittsburgh Sleep Quality Index) and global and domain-specific (language, executive function, episodic memory, and simple attention) cognitive function. Multivariable linear regressions estimated the associations between sleep quality quartiles and overall and domain-specific cognitive function adjusting for age, sex, race/ethnicity, education, depressive symptoms, and severe hypoglycemic episodes. Sensitivity analyses examined the associations between aspects of sleep quality and global cognitive function.Results:The worst sleep quality quartile was associated with lower global cognition (β=-0.08; 95% confidence interval:-0.17,-0.01) and lower executive function (β=-0.17, 95% confidence interval:-0.30,-0.03) compared with the best quartile of sleep quality adjusting for demographics and comorbidities. Sleep quality was not associated with language, episodic memory, or simple attention. Sleep medications and daytime dysfunction were most strongly associated with global cognition.Conclusion:Our results suggest that sleep quality may be a modifiable risk factor for global cognitive function and executive function among elderly individuals with T1D.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalAlzheimer Disease and Associated Disorders
Issue number1
StatePublished - 2020

Bibliographical note

Publisher Copyright:
© 2019 Wolters Kluwer Health, Inc. All rights reserved.


  • cognitive function
  • sleep quality
  • type 1 diabetes

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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