TY - JOUR
T1 - Small molecule inhibitors of the fosfomycin resistance enzyme FosM from Mycobacterium abscessus
AU - Chiasson, Skye
AU - Smith, Tatum
AU - Bello, Landon
AU - Chandrika, Nishad Thamban
AU - Green, Keith D.
AU - Garneau-Tsodikova, Sylvie
AU - Thompson, Matthew K.
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/10
Y1 - 2023/10
N2 - Fosfomycin is a safe broad-spectrum antibiotic that has not achieved widespread use because of the emergence of fosfomycin-modifying enzymes. Inhibition of fosfomycin-modifying enzymes could be used to help combat pathogens like Mycobacterium abscessus. Our previous work identified several inhibitors for the enzyme FosB from Staphylococcus aureus. We have tested those same compounds for inhibition of FosM, the fosfomycin-modifying enzyme from M. abscessus. The work described here will be used as the basis for more detailed studies into the inhibition of FosM.
AB - Fosfomycin is a safe broad-spectrum antibiotic that has not achieved widespread use because of the emergence of fosfomycin-modifying enzymes. Inhibition of fosfomycin-modifying enzymes could be used to help combat pathogens like Mycobacterium abscessus. Our previous work identified several inhibitors for the enzyme FosB from Staphylococcus aureus. We have tested those same compounds for inhibition of FosM, the fosfomycin-modifying enzyme from M. abscessus. The work described here will be used as the basis for more detailed studies into the inhibition of FosM.
KW - Antimicrobial resistance
KW - ForM
KW - Fosfomycin
KW - Mycobacterium abscessus
UR - http://www.scopus.com/inward/record.url?scp=85168154185&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85168154185&partnerID=8YFLogxK
U2 - 10.1016/j.bbagen.2023.130444
DO - 10.1016/j.bbagen.2023.130444
M3 - Article
C2 - 37579984
AN - SCOPUS:85168154185
SN - 0304-4165
VL - 1867
JO - Biochimica et Biophysica Acta - General Subjects
JF - Biochimica et Biophysica Acta - General Subjects
IS - 10
M1 - 130444
ER -