Addition of biodegradable polymer shells surrounding polymeric, drug-loaded microparticles offers the opportunity to control drug release rates. A novel fabrication method was used to produce microparticles with precise control of particle diameter and the thickness of the polymer shell. The effect of shell thickness on release of a model drug, piroxicam, has been clearly shown for 2- to 15-μm thick shells of poly(D,L-lactide) (PDLL) surrounding a poly(D,L-lactide-co-glycolide) (PLG) core and compared to pure PLG microspheres loaded with piroxicam. Furthermore, the core-shell microparticles are compared to microspheres containing blended polymers in the same mass ratios to demonstrate the importance of the core-shell morphology. Combining PDLL(PLG) microcapsules of different shell thicknesses allows nearly constant release rates to be attained for a period of 6 weeks.
|Number of pages||10|
|Journal||Journal of Pharmaceutical Sciences|
|State||Published - Sep 2005|
Bibliographical noteFunding Information:
This work was supported by NIH grant 1-R21-ED002878. The gift of piroxicam from Dong Wha Pharmaceuticals is also gratefully acknowledged. Scanning electron microscopy was carried out at the Center for Microanalysis of Materials, University of Illinois at Urbana-Champaign, which is partially supported by the U.S. Department of Energy under grant DEFG02-91-ER45439.
- Controlled release
ASJC Scopus subject areas
- Pharmaceutical Science