Smart polymeric micelles for gene and drug delivery

Nobuhiro Nishiyama; Younsoo Bae; Kanjiro Miyata; Shigeto Fukushima; Kazunori Kataoka

doi:10.1016/j.ddtec.2005.05.007

Smart polymeric micelles for gene and drug delivery

Nobuhiro Nishiyama, Younsoo Bae, Kanjiro Miyata, Shigeto Fukushima, Kazunori Kataoka

Pharmaceutical Sciences

Research output: Contribution to journal › Review article › peer-review

114 Scopus citations

Abstract

Polymeric micelles, supramolecular assemblies of block copolymers, are useful nanocarriers for the systemic delivery of drugs and genes. Recently, novel polymeric micelles with smart functions, such as targetability and stimuli-sensitivity, have emerged as promising carriers that enhance the efficacy of drugs and genes with minimal side effects. This review focuses on the construction and characteristic behaviors of intracellular environment-sensitive micelles that selectively exert drug activity and gene expression in live cells.

Original language	English
Pages (from-to)	21-26
Number of pages	6
Journal	Drug Discovery Today: Technologies
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/j.ddtec.2005.05.007
State	Published - 2005

Bibliographical note

Funding Information:
This work was supported in part by the Core Research for Evolutional Science and Technology (CREST) from the Japan Science and Technology Agency (JST).

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddtec.2005.05.007

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author = "Nobuhiro Nishiyama and Younsoo Bae and Kanjiro Miyata and Shigeto Fukushima and Kazunori Kataoka",

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T1 - Smart polymeric micelles for gene and drug delivery

AU - Nishiyama, Nobuhiro

AU - Bae, Younsoo

AU - Miyata, Kanjiro

AU - Fukushima, Shigeto

AU - Kataoka, Kazunori

N1 - Funding Information: This work was supported in part by the Core Research for Evolutional Science and Technology (CREST) from the Japan Science and Technology Agency (JST).

PY - 2005

Y1 - 2005

N2 - Polymeric micelles, supramolecular assemblies of block copolymers, are useful nanocarriers for the systemic delivery of drugs and genes. Recently, novel polymeric micelles with smart functions, such as targetability and stimuli-sensitivity, have emerged as promising carriers that enhance the efficacy of drugs and genes with minimal side effects. This review focuses on the construction and characteristic behaviors of intracellular environment-sensitive micelles that selectively exert drug activity and gene expression in live cells.

AB - Polymeric micelles, supramolecular assemblies of block copolymers, are useful nanocarriers for the systemic delivery of drugs and genes. Recently, novel polymeric micelles with smart functions, such as targetability and stimuli-sensitivity, have emerged as promising carriers that enhance the efficacy of drugs and genes with minimal side effects. This review focuses on the construction and characteristic behaviors of intracellular environment-sensitive micelles that selectively exert drug activity and gene expression in live cells.

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DO - 10.1016/j.ddtec.2005.05.007

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EP - 26

JO - Drug Discovery Today: Technologies

JF - Drug Discovery Today: Technologies

IS - 1

ER -

Smart polymeric micelles for gene and drug delivery

Abstract

Bibliographical note

ASJC Scopus subject areas

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