Polymeric micelles, supramolecular assemblies of block copolymers, are useful nanocarriers for the systemic delivery of drugs and genes. Recently, novel polymeric micelles with smart functions, such as targetability and stimuli-sensitivity, have emerged as promising carriers that enhance the efficacy of drugs and genes with minimal side effects. This review focuses on the construction and characteristic behaviors of intracellular environment-sensitive micelles that selectively exert drug activity and gene expression in live cells.
|Number of pages||6|
|Journal||Drug Discovery Today: Technologies|
|State||Published - 2005|
Bibliographical noteFunding Information:
This work was supported in part by the Core Research for Evolutional Science and Technology (CREST) from the Japan Science and Technology Agency (JST).
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery