Smart polymeric micelles for gene and drug delivery

Nobuhiro Nishiyama, Younsoo Bae, Kanjiro Miyata, Shigeto Fukushima, Kazunori Kataoka

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations


Polymeric micelles, supramolecular assemblies of block copolymers, are useful nanocarriers for the systemic delivery of drugs and genes. Recently, novel polymeric micelles with smart functions, such as targetability and stimuli-sensitivity, have emerged as promising carriers that enhance the efficacy of drugs and genes with minimal side effects. This review focuses on the construction and characteristic behaviors of intracellular environment-sensitive micelles that selectively exert drug activity and gene expression in live cells.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalDrug Discovery Today: Technologies
Issue number1
StatePublished - 2005

Bibliographical note

Funding Information:
This work was supported in part by the Core Research for Evolutional Science and Technology (CREST) from the Japan Science and Technology Agency (JST).

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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