Smoking initiation and schizophrenia: A replication study in a Spanish sample

Manuel Gurpegui, José M. Martínez-Ortega, M. Carmen Aguilar, Francisco J. Diaz, Hernando M. Quintana, Jose De Leon

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


In a prior US study, schizophrenia vulnerability was associated with higher risk of initiating daily smoking after 20 years of age. A survival analysis of onset age of daily smoking compared 290 controls with 250 consecutive DSM-IV schizophrenia patients from outpatient facilities at an urban catchment area in Spain. After controlling for gender and education, the cumulative hazard curves for smoking initiation age of controls and schizophrenia patients were significantly different. After age 20, smoking initiation rates were higher in all schizophrenia patients (and in 107 schizophrenia patients who started daily smoking at least 5 years before illness onset).

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalSchizophrenia Research
Issue number1
StatePublished - Jul 1 2005

Bibliographical note

Funding Information:
The authors are grateful to the patients and staff of the Granada-South and Granada-North Community Mental Health Centers and their rehabilitation unit. Dr. Aguilar was supported by a Spanish Agency for International Cooperation (A.E.C.I.) grant. Dr. Diaz was partially supported by a grant from the Dirección de Investigaciones de la Universidad Nacional, Medellín. Juan Rivero, R.N., helped with data collection and Margaret T. Susce, R.N., M.L.T., with editing. Comments from a reviewer led us to consider the possibility of longer prodromal periods than 2 years, and the need for other survival analyses.


  • Cumulative hazard curves
  • Schizophrenia
  • Smoking initiation
  • Survival analysis
  • Tobacco

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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