Smoothened regulation in response to Hedgehog stimulation

Kai Jiang; Jianhang Jia

doi:10.1007/s11515-015-1385-8

Smoothened regulation in response to Hedgehog stimulation

Kai Jiang, Jianhang Jia

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

The Hedgehog (Hh) signaling pathway play critical roles in embryonic development and adult tissue homeostasis. A critical step in Hh signal transduction is how Hh receptor Patched (Ptc) inhibits the atypical G proteincoupled receptor Smoothened (Smo) in the absence of Hh and how this inhibition is release by Hh stimulation. It is unlikely that Ptc inhibits Smo by direct interaction. Here we discuss how Hh regulates the phosphorylation and ubiquitination of Smo, leading to cell surface and ciliary accumulation of Smo in Drosophila and vertebrate cells, respectively. In addition, we discuss how PI(4)P phospholipid acts in between Ptc and Smo to regulate Smo phosphorylation and activation in response to Hh stimulation.

Original language	English
Pages (from-to)	475-486
Number of pages	12
Journal	Frontiers in Biology
Volume	10
Issue number	6
DOIs	https://doi.org/10.1007/s11515-015-1385-8
State	Published - Dec 1 2015

Bibliographical note

Publisher Copyright:
© 2015, Higher Education Press and Springer-Verlag Berlin Heidelberg.

Keywords

Hh signaling
Smo
phospholipid
phosphorylation
signal transduction
ubiquitination

ASJC Scopus subject areas

Biotechnology
Ecology, Evolution, Behavior and Systematics
Ecology
Genetics

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10.1007/s11515-015-1385-8

Cite this

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abstract = "The Hedgehog (Hh) signaling pathway play critical roles in embryonic development and adult tissue homeostasis. A critical step in Hh signal transduction is how Hh receptor Patched (Ptc) inhibits the atypical G proteincoupled receptor Smoothened (Smo) in the absence of Hh and how this inhibition is release by Hh stimulation. It is unlikely that Ptc inhibits Smo by direct interaction. Here we discuss how Hh regulates the phosphorylation and ubiquitination of Smo, leading to cell surface and ciliary accumulation of Smo in Drosophila and vertebrate cells, respectively. In addition, we discuss how PI(4)P phospholipid acts in between Ptc and Smo to regulate Smo phosphorylation and activation in response to Hh stimulation.",

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AU - Jiang, Kai

AU - Jia, Jianhang

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N2 - The Hedgehog (Hh) signaling pathway play critical roles in embryonic development and adult tissue homeostasis. A critical step in Hh signal transduction is how Hh receptor Patched (Ptc) inhibits the atypical G proteincoupled receptor Smoothened (Smo) in the absence of Hh and how this inhibition is release by Hh stimulation. It is unlikely that Ptc inhibits Smo by direct interaction. Here we discuss how Hh regulates the phosphorylation and ubiquitination of Smo, leading to cell surface and ciliary accumulation of Smo in Drosophila and vertebrate cells, respectively. In addition, we discuss how PI(4)P phospholipid acts in between Ptc and Smo to regulate Smo phosphorylation and activation in response to Hh stimulation.

AB - The Hedgehog (Hh) signaling pathway play critical roles in embryonic development and adult tissue homeostasis. A critical step in Hh signal transduction is how Hh receptor Patched (Ptc) inhibits the atypical G proteincoupled receptor Smoothened (Smo) in the absence of Hh and how this inhibition is release by Hh stimulation. It is unlikely that Ptc inhibits Smo by direct interaction. Here we discuss how Hh regulates the phosphorylation and ubiquitination of Smo, leading to cell surface and ciliary accumulation of Smo in Drosophila and vertebrate cells, respectively. In addition, we discuss how PI(4)P phospholipid acts in between Ptc and Smo to regulate Smo phosphorylation and activation in response to Hh stimulation.

KW - Hh signaling

KW - Smo

KW - phospholipid

KW - phosphorylation

KW - signal transduction

KW - ubiquitination

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U2 - 10.1007/s11515-015-1385-8

DO - 10.1007/s11515-015-1385-8

M3 - Review article

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SN - 1674-7984

VL - 10

SP - 475

EP - 486

JO - Frontiers in Biology

JF - Frontiers in Biology

IS - 6

ER -

Smoothened regulation in response to Hedgehog stimulation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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