Smoothened regulation in response to Hedgehog stimulation

Kai Jiang, Jianhang Jia

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


The Hedgehog (Hh) signaling pathway play critical roles in embryonic development and adult tissue homeostasis. A critical step in Hh signal transduction is how Hh receptor Patched (Ptc) inhibits the atypical G proteincoupled receptor Smoothened (Smo) in the absence of Hh and how this inhibition is release by Hh stimulation. It is unlikely that Ptc inhibits Smo by direct interaction. Here we discuss how Hh regulates the phosphorylation and ubiquitination of Smo, leading to cell surface and ciliary accumulation of Smo in Drosophila and vertebrate cells, respectively. In addition, we discuss how PI(4)P phospholipid acts in between Ptc and Smo to regulate Smo phosphorylation and activation in response to Hh stimulation.

Original languageEnglish
Pages (from-to)475-486
Number of pages12
JournalFrontiers in Biology
Issue number6
StatePublished - Dec 1 2015

Bibliographical note

Publisher Copyright:
© 2015, Higher Education Press and Springer-Verlag Berlin Heidelberg.


  • Hh signaling
  • Smo
  • phospholipid
  • phosphorylation
  • signal transduction
  • ubiquitination

ASJC Scopus subject areas

  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Genetics


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