Abstract
The Hedgehog (Hh) signaling pathway play critical roles in embryonic development and adult tissue homeostasis. A critical step in Hh signal transduction is how Hh receptor Patched (Ptc) inhibits the atypical G proteincoupled receptor Smoothened (Smo) in the absence of Hh and how this inhibition is release by Hh stimulation. It is unlikely that Ptc inhibits Smo by direct interaction. Here we discuss how Hh regulates the phosphorylation and ubiquitination of Smo, leading to cell surface and ciliary accumulation of Smo in Drosophila and vertebrate cells, respectively. In addition, we discuss how PI(4)P phospholipid acts in between Ptc and Smo to regulate Smo phosphorylation and activation in response to Hh stimulation.
| Original language | English |
|---|---|
| Pages (from-to) | 475-486 |
| Number of pages | 12 |
| Journal | Frontiers in Biology |
| Volume | 10 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2015 |
Bibliographical note
Publisher Copyright:© 2015, Higher Education Press and Springer-Verlag Berlin Heidelberg.
Funding
We apologize to colleagues whose works were not cited because of space limited. Our work is supported by funding from the National Institute of Health (R01GM079684).
| Funders | Funder number |
|---|---|
| Foundation for the National Institutes of Health | R01GM079684 |
Keywords
- Hh signaling
- Smo
- phospholipid
- phosphorylation
- signal transduction
- ubiquitination
ASJC Scopus subject areas
- Biotechnology
- Ecology, Evolution, Behavior and Systematics
- Ecology
- Genetics