Snail has moved into the fast lane of development and cancer biology with the epithelial-mesenchymal transition (EMT) emerging as one of the hottest topics in medical science within the past few years. Snail not only acts primarily as a key inducer of EMT but also plays important role in cell survival, immune regulation and stem cell biology. This review focuses on the regulation of Snail and discusses the EMT-dependent and -independent functions of Snail in development and disease. Understanding the regulation and functional roles of Snail will shed new light on the mechanism of tumor progression and the development of novel cancer therapies.
Bibliographical noteFunding Information:
We thank all the investigators that contribute to the Snail field and we apologize to those whose work is important but that we are unable to cite here. Our study is supported by grants from NIH (RO1CA125454), the Susan G. Komen Foundation (KG081310) and the Mary Kay Ash Foundation (to B.P. Z.).
- Stem cell
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Cell Biology