SNAP family of NSF attachment proteins includes a brain-specific isoform

Sidney W. Whiteheart, Irene C. Griff, Michael Brunner, Douglas O. Clary, Thomas Mayer, Susan A. Buhrow, James E. Rothman

Research output: Contribution to journalArticlepeer-review

223 Scopus citations

Abstract

THE soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide- sensitive fusion protein (NSF) to bind to target mem-branes1-4. Here we report the cloning and sequencing of com-plementary DNAs encoding α-, β- and γ-SNAPs. Two of these proteins, α and γ, are found in a wide range of tissues, and act synergistically in intra-Golgi transport. The third, β, is a brain-specific isoform of α-SNAP. Thus, NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused, as described in the accompanying article4.

Original languageEnglish
Pages (from-to)353-355
Number of pages3
JournalNature
Volume362
Issue number6418
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'SNAP family of NSF attachment proteins includes a brain-specific isoform'. Together they form a unique fingerprint.

Cite this