Soluble Prorenin Receptor Increases Blood Pressure in High Fat-Fed Male Mice

Eva Gatineau, Ming C. Gong, Frédérique Yiannikouris

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Obesity-related hypertension is a major public health concern. We recently demonstrated that plasma levels of the soluble form of the prorenin receptor (sPRR) were elevated in obesity-associated hypertension. Therefore, in the present study, we investigated the contribution of sPRR to blood pressure (BP) elevation in the context of obesity. High fat-fed C57BL/6 male mice were infused with vehicle or sPRR (30 μg/kg per day) via subcutaneously implanted osmotic minipump for 4 weeks. BP parameters were recorded using radiotelemetry devices. Male mice infused with sPRR exhibited higher systolic BP and mean arterial pressure and lower spontaneous baroreflex sensitivity than mice infused with vehicle. To define mechanisms involved in systolic BP elevation, mice were injected with an AT1R (Ang II [angiotensin II] type 1 receptor) antagonist (losartan), a muscarinic receptor antagonist (atropine), a β-adrenergic antagonist (propranolol), and a ganglionic blocker (chlorisondamine). Losartan did not blunt sPRR-induced elevation in systolic BP. Chlorisondamine treatment exacerbated the decrease in mean arterial pressure in male mice infused with sPRR. These results demonstrated that sPRR induced autonomic nervous dysfunction. Interestingly, plasma leptin levels were increased in high fat-fed C57BL/6 male mice infused with sPRR. Overall, our results indicated that sPRR increased systolic BP through an impairment of the baroreflex sensitivity and an increase in the sympathetic tone potentially mediated by leptin in high fat-fed C57BL/6 male mice.

Original languageEnglish
Pages (from-to)1014-1020
Number of pages7
JournalHypertension
Volume74
Issue number4
DOIs
StatePublished - Oct 1 2019

Bibliographical note

Publisher Copyright:
© 2019 American Heart Association, Inc.

Keywords

  • blood pressure
  • leptin
  • obesity
  • soluble prorenin receptor

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint

Dive into the research topics of 'Soluble Prorenin Receptor Increases Blood Pressure in High Fat-Fed Male Mice'. Together they form a unique fingerprint.

Cite this