TY - JOUR
T1 - Sonographic findings of trisomy 18 in the second trimester of pregnancy
AU - Watson, William J.
AU - Miller, Richard C.
AU - Wax, Joseph R.
AU - Hansen, Wendy F.
AU - Yamamura, Yasuko
AU - Polzin, William J.
PY - 2008/7
Y1 - 2008/7
N2 - Objective. The purpose of this study was to examine the sonographic findings in fetuses with trisomy 18 in the second trimester of pregnancy. Methods. A retrospective review of the cytogenetic laboratory databases at 6 tertiary referral centers identified all cases of trisomy 18. The prenatal sonographic studies in fetuses at 15 to 21 weeks' gestation, done before invasive testing for the karyotype, were reviewed for anatomic and biometric findings. We defined abnormal fetal biometric findings as a biometric measurement (biparietal diameter, abdominal circumference, or femur length) below the fifth percentile in the second trimester. Results. Of 98 fetuses with trisomy 18, 95 (97%) were detected sonographically; an anomaly was found in 92 (94%). A biometric measurement below the fifth percentile was noted in 50 (51 %). Cardiac (63%) and central nervous system (34%) anomalies were most frequently detected. Although choroid plexus cysts were commonly seen, no fetuses with trisomy 18 and isolated choroid plexus cysts were found. Conclusions. Targeted sonography identified abnormal fetal anatomy or abnormal biometric findings in 97% of fetuses with trisomy 18 in the second trimester. A biometric measurement below the fifth percentile was noted in half of the cases in the second trimester.
AB - Objective. The purpose of this study was to examine the sonographic findings in fetuses with trisomy 18 in the second trimester of pregnancy. Methods. A retrospective review of the cytogenetic laboratory databases at 6 tertiary referral centers identified all cases of trisomy 18. The prenatal sonographic studies in fetuses at 15 to 21 weeks' gestation, done before invasive testing for the karyotype, were reviewed for anatomic and biometric findings. We defined abnormal fetal biometric findings as a biometric measurement (biparietal diameter, abdominal circumference, or femur length) below the fifth percentile in the second trimester. Results. Of 98 fetuses with trisomy 18, 95 (97%) were detected sonographically; an anomaly was found in 92 (94%). A biometric measurement below the fifth percentile was noted in 50 (51 %). Cardiac (63%) and central nervous system (34%) anomalies were most frequently detected. Although choroid plexus cysts were commonly seen, no fetuses with trisomy 18 and isolated choroid plexus cysts were found. Conclusions. Targeted sonography identified abnormal fetal anatomy or abnormal biometric findings in 97% of fetuses with trisomy 18 in the second trimester. A biometric measurement below the fifth percentile was noted in half of the cases in the second trimester.
KW - Prenatal diagnosis
KW - Sonography
KW - Trisomy 18
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U2 - 10.7863/jum.2008.27.7.1033
DO - 10.7863/jum.2008.27.7.1033
M3 - Review article
C2 - 18577667
AN - SCOPUS:47249102994
SN - 0278-4297
VL - 27
SP - 1033
EP - 1038
JO - Journal of Ultrasound in Medicine
JF - Journal of Ultrasound in Medicine
IS - 7
ER -