TY - JOUR
T1 - Spared behavioral repetition effects in Alzheimer’s disease linked to an altered neural mechanism at posterior cortex
AU - Broster, Lucas S.
AU - Li, Juan
AU - Wagner, Benjamin
AU - Smith, Charles D.
AU - Jicha, Gregory A.
AU - Schmitt, Frederick A.
AU - Munro, Nancy
AU - Haney, Ryan H.
AU - Jiang, Yang
N1 - Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/9/14
Y1 - 2018/9/14
N2 - Objective: Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex. Method: Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects. Results: Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect. Conclusion: Visual cortex may play a role in maintained repetition effects in persons with early AD.
AB - Objective: Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex. Method: Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects. Results: Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect. Conclusion: Visual cortex may play a role in maintained repetition effects in persons with early AD.
KW - Alzheimer’s disease
KW - event-related potentials
KW - mild cognitive impairment
KW - repetition effects
KW - working memory
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U2 - 10.1080/13803395.2018.1430230
DO - 10.1080/13803395.2018.1430230
M3 - Article
C2 - 29463181
AN - SCOPUS:85042232521
SN - 1380-3395
VL - 40
SP - 761
EP - 776
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
IS - 8
ER -