Spared behavioral repetition effects in Alzheimer’s disease linked to an altered neural mechanism at posterior cortex

Lucas S. Broster; Juan Li; Benjamin Wagner; Charles D. Smith; Gregory A. Jicha; Frederick A. Schmitt; Nancy Munro; Ryan H. Haney; Yang Jiang

doi:10.1080/13803395.2018.1430230

Spared behavioral repetition effects in Alzheimer’s disease linked to an altered neural mechanism at posterior cortex

Lucas S. Broster, Juan Li, Benjamin Wagner, Charles D. Smith, Gregory A. Jicha, Frederick A. Schmitt, Nancy Munro, Ryan H. Haney, Yang Jiang

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective: Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex. Method: Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects. Results: Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect. Conclusion: Visual cortex may play a role in maintained repetition effects in persons with early AD.

Original language	English
Pages (from-to)	761-776
Number of pages	16
Journal	Journal of Clinical and Experimental Neuropsychology
Volume	40
Issue number	8
DOIs	https://doi.org/10.1080/13803395.2018.1430230
State	Published - Sep 14 2018

Bibliographical note

Funding Information:
This work was supported by a pilot grant from the University of Kentucky Department of Behavioral Science; the U.S. Department of Energy [grant number DE-AC03-OR22725]; and the National Institute of Health: National Institute on Aging [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 810 5 T32 AG 242-18], the National Institute of Mental Health [grant number R25 MH060482], and the National Center for Advancing Translational Sciences [grant number UL1RR033173], [grant number UL1TR000117].

Funding Information:
This work was supported by a pilot grant from the University of Kentucky Department of Behavioral Science; the U.S. Department of Energy [grant number DE-AC03-OR22725]; and the National Institute of Health: National Institute on Aging [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 810 5 T32 AG 242-18], the National Institute of Mental Health [grant number R25 MH060482], and the National Center for Advancing Translational Sciences [grant number UL1RR033173], [grant number UL1TR000117]. We would like to thank C. Black, S. Kiser, and E. Walsh for their assistance in behavioral data collection, and we would like to thank A. Lawson for assistance in task development. We would like to thank R. Kryscio, E. Abner, and the University of Kentucky Alzheimer Disease Center (UK-ADC) for their help with the compilation of the neuropsychological test results. We would like to thank J. Dien for assistance in use of his ERP Toolkit software. We have no financial or material conflicts of interest to report.

Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

Alzheimer’s disease
event-related potentials
mild cognitive impairment
repetition effects
working memory

ASJC Scopus subject areas

Clinical Psychology
Neurology
Clinical Neurology

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10.1080/13803395.2018.1430230

Cite this

@article{fd52aa9326804907a0de2edaf9e442b6,

title = "Spared behavioral repetition effects in Alzheimer{\textquoteright}s disease linked to an altered neural mechanism at posterior cortex",

abstract = "Objective: Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex. Method: Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects. Results: Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect. Conclusion: Visual cortex may play a role in maintained repetition effects in persons with early AD.",

keywords = "Alzheimer{\textquoteright}s disease, event-related potentials, mild cognitive impairment, repetition effects, working memory",

author = "Broster, {Lucas S.} and Juan Li and Benjamin Wagner and Smith, {Charles D.} and Jicha, {Gregory A.} and Schmitt, {Frederick A.} and Nancy Munro and Haney, {Ryan H.} and Yang Jiang",

note = "Funding Information: This work was supported by a pilot grant from the University of Kentucky Department of Behavioral Science; the U.S. Department of Energy [grant number DE-AC03-OR22725]; and the National Institute of Health: National Institute on Aging [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 810 5 T32 AG 242-18], the National Institute of Mental Health [grant number R25 MH060482], and the National Center for Advancing Translational Sciences [grant number UL1RR033173], [grant number UL1TR000117]. Funding Information: This work was supported by a pilot grant from the University of Kentucky Department of Behavioral Science; the U.S. Department of Energy [grant number DE-AC03-OR22725]; and the National Institute of Health: National Institute on Aging [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 810 5 T32 AG 242-18], the National Institute of Mental Health [grant number R25 MH060482], and the National Center for Advancing Translational Sciences [grant number UL1RR033173], [grant number UL1TR000117]. We would like to thank C. Black, S. Kiser, and E. Walsh for their assistance in behavioral data collection, and we would like to thank A. Lawson for assistance in task development. We would like to thank R. Kryscio, E. Abner, and the University of Kentucky Alzheimer Disease Center (UK-ADC) for their help with the compilation of the neuropsychological test results. We would like to thank J. Dien for assistance in use of his ERP Toolkit software. We have no financial or material conflicts of interest to report. Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2018",

month = sep,

day = "14",

doi = "10.1080/13803395.2018.1430230",

language = "English",

volume = "40",

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T1 - Spared behavioral repetition effects in Alzheimer’s disease linked to an altered neural mechanism at posterior cortex

AU - Broster, Lucas S.

AU - Li, Juan

AU - Wagner, Benjamin

AU - Smith, Charles D.

AU - Jicha, Gregory A.

AU - Schmitt, Frederick A.

AU - Munro, Nancy

AU - Haney, Ryan H.

AU - Jiang, Yang

N1 - Funding Information: This work was supported by a pilot grant from the University of Kentucky Department of Behavioral Science; the U.S. Department of Energy [grant number DE-AC03-OR22725]; and the National Institute of Health: National Institute on Aging [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 810 5 T32 AG 242-18], the National Institute of Mental Health [grant number R25 MH060482], and the National Center for Advancing Translational Sciences [grant number UL1RR033173], [grant number UL1TR000117]. Funding Information: This work was supported by a pilot grant from the University of Kentucky Department of Behavioral Science; the U.S. Department of Energy [grant number DE-AC03-OR22725]; and the National Institute of Health: National Institute on Aging [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 810 5 T32 AG 242-18], the National Institute of Mental Health [grant number R25 MH060482], and the National Center for Advancing Translational Sciences [grant number UL1RR033173], [grant number UL1TR000117]. We would like to thank C. Black, S. Kiser, and E. Walsh for their assistance in behavioral data collection, and we would like to thank A. Lawson for assistance in task development. We would like to thank R. Kryscio, E. Abner, and the University of Kentucky Alzheimer Disease Center (UK-ADC) for their help with the compilation of the neuropsychological test results. We would like to thank J. Dien for assistance in use of his ERP Toolkit software. We have no financial or material conflicts of interest to report. Publisher Copyright: © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2018/9/14

Y1 - 2018/9/14

N2 - Objective: Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex. Method: Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects. Results: Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect. Conclusion: Visual cortex may play a role in maintained repetition effects in persons with early AD.

AB - Objective: Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex. Method: Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects. Results: Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect. Conclusion: Visual cortex may play a role in maintained repetition effects in persons with early AD.

KW - Alzheimer’s disease

KW - event-related potentials

KW - mild cognitive impairment

KW - repetition effects

KW - working memory

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SN - 1380-3395

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EP - 776

JO - Journal of Clinical and Experimental Neuropsychology

JF - Journal of Clinical and Experimental Neuropsychology

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ER -

Spared behavioral repetition effects in Alzheimer’s disease linked to an altered neural mechanism at posterior cortex

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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