Spared behavioral repetition effects in Alzheimer’s disease linked to an altered neural mechanism at posterior cortex

Lucas S. Broster, Juan Li, Benjamin Wagner, Charles D. Smith, Gregory A. Jicha, Frederick A. Schmitt, Nancy Munro, Ryan H. Haney, Yang Jiang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex. Method: Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects. Results: Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect. Conclusion: Visual cortex may play a role in maintained repetition effects in persons with early AD.

Original languageEnglish
Pages (from-to)761-776
Number of pages16
JournalJournal of Clinical and Experimental Neuropsychology
Volume40
Issue number8
DOIs
StatePublished - Sep 14 2018

Bibliographical note

Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Alzheimer’s disease
  • event-related potentials
  • mild cognitive impairment
  • repetition effects
  • working memory

ASJC Scopus subject areas

  • Clinical Psychology
  • Neurology
  • Clinical Neurology

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