Spatial distribution of endogenous retinoids in the murine embryonic mandible

Jan E. Kronmiller; Cynthia S. Beeman

doi:10.1016/0003-9969(94)90060-4

Spatial distribution of endogenous retinoids in the murine embryonic mandible

Jan E. Kronmiller, Cynthia S. Beeman

Oral Health Science

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Retinoids play an important part in pattern formation during embryonic development. Exogenous retinoids alter the pattern of skeletal, neural and odontogenic tissues. Endogenous retinoids have been demonstrated previously in the murine embryonic mandible, reaching a concentration peak during the initiation of odontogenesis. It was now found that endogenous retinoids are present in a concentration gradient in the embryonic mouse mandible at the time of the initiation of the dental lamina. All-trans-retinoic acid was more concentrated in the incisor region and retinol in the molar region. These results, and the fact that exogenous retinoids produce supernumerary incisors and missing molars, suggest that all-trans-retinoic acid may instruct incisor morphology.

Original language	English
Pages (from-to)	1071-1078
Number of pages	8
Journal	Archives of Oral Biology
Volume	39
Issue number	12
DOIs	https://doi.org/10.1016/0003-9969(94)90060-4
State	Published - Dec 1994

Bibliographical note

Funding Information:
AcknoM,ledgemenrs-This work was supported by a grant from the American Association of Orthodontists (JEK and CSB) and USPHS/NIH Grants DEOO286-03 (JEK) and DE10839-01 (JEK).

Keywords

concentration gradient
embryonic
endogenous retinoids
mandible
spatial distribution

ASJC Scopus subject areas

Otorhinolaryngology
General Dentistry
Cell Biology

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10.1016/0003-9969(94)90060-4

Cite this

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title = "Spatial distribution of endogenous retinoids in the murine embryonic mandible",

abstract = "Retinoids play an important part in pattern formation during embryonic development. Exogenous retinoids alter the pattern of skeletal, neural and odontogenic tissues. Endogenous retinoids have been demonstrated previously in the murine embryonic mandible, reaching a concentration peak during the initiation of odontogenesis. It was now found that endogenous retinoids are present in a concentration gradient in the embryonic mouse mandible at the time of the initiation of the dental lamina. All-trans-retinoic acid was more concentrated in the incisor region and retinol in the molar region. These results, and the fact that exogenous retinoids produce supernumerary incisors and missing molars, suggest that all-trans-retinoic acid may instruct incisor morphology.",

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note = "Funding Information: AcknoM,ledgemenrs-This work was supported by a grant from the American Association of Orthodontists (JEK and CSB) and USPHS/NIH Grants DEOO286-03 (JEK) and DE10839-01 (JEK).",

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AU - Kronmiller, Jan E.

AU - Beeman, Cynthia S.

N1 - Funding Information: AcknoM,ledgemenrs-This work was supported by a grant from the American Association of Orthodontists (JEK and CSB) and USPHS/NIH Grants DEOO286-03 (JEK) and DE10839-01 (JEK).

PY - 1994/12

Y1 - 1994/12

N2 - Retinoids play an important part in pattern formation during embryonic development. Exogenous retinoids alter the pattern of skeletal, neural and odontogenic tissues. Endogenous retinoids have been demonstrated previously in the murine embryonic mandible, reaching a concentration peak during the initiation of odontogenesis. It was now found that endogenous retinoids are present in a concentration gradient in the embryonic mouse mandible at the time of the initiation of the dental lamina. All-trans-retinoic acid was more concentrated in the incisor region and retinol in the molar region. These results, and the fact that exogenous retinoids produce supernumerary incisors and missing molars, suggest that all-trans-retinoic acid may instruct incisor morphology.

AB - Retinoids play an important part in pattern formation during embryonic development. Exogenous retinoids alter the pattern of skeletal, neural and odontogenic tissues. Endogenous retinoids have been demonstrated previously in the murine embryonic mandible, reaching a concentration peak during the initiation of odontogenesis. It was now found that endogenous retinoids are present in a concentration gradient in the embryonic mouse mandible at the time of the initiation of the dental lamina. All-trans-retinoic acid was more concentrated in the incisor region and retinol in the molar region. These results, and the fact that exogenous retinoids produce supernumerary incisors and missing molars, suggest that all-trans-retinoic acid may instruct incisor morphology.

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KW - embryonic

KW - endogenous retinoids

KW - mandible

KW - spatial distribution

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Spatial distribution of endogenous retinoids in the murine embryonic mandible

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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