Spatial distribution of endogenous retinoids in the murine embryonic mandible

Jan E. Kronmiller, Cynthia S. Beeman

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Retinoids play an important part in pattern formation during embryonic development. Exogenous retinoids alter the pattern of skeletal, neural and odontogenic tissues. Endogenous retinoids have been demonstrated previously in the murine embryonic mandible, reaching a concentration peak during the initiation of odontogenesis. It was now found that endogenous retinoids are present in a concentration gradient in the embryonic mouse mandible at the time of the initiation of the dental lamina. All-trans-retinoic acid was more concentrated in the incisor region and retinol in the molar region. These results, and the fact that exogenous retinoids produce supernumerary incisors and missing molars, suggest that all-trans-retinoic acid may instruct incisor morphology.

Original languageEnglish
Pages (from-to)1071-1078
Number of pages8
JournalArchives of Oral Biology
Issue number12
StatePublished - Dec 1994

Bibliographical note

Funding Information:
AcknoM,ledgemenrs-This work was supported by a grant from the American Association of Orthodontists (JEK and CSB) and USPHS/NIH Grants DEOO286-03 (JEK) and DE10839-01 (JEK).


  • concentration gradient
  • embryonic
  • endogenous retinoids
  • mandible
  • spatial distribution

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry (all)
  • Cell Biology


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