Abstract
We adapted and tested an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) system for 3D imaging of cerebral blood flow (CBF) variations in perinatal disease models utilizing neonatal piglets, which closely resemble human neonates. CBF variations were concurrently measured by the scDCT and an established diffuse correlation spectroscopy (DCS) during global ischemia, intraventricular hemorrhage, and asphyxia; significant correlations were observed. Moreover, CBF variations associated reasonably with vital pathophysiological changes. In contrast to DCS measurements of mixed signals from local scalp, skull and brain, scDCT generates 3D images of CBF distributions at prescribed depths within the head, thus enabling specific determination of regional cerebral ischemia. With further optimization and validation in animals and human neonates, scDCT has the potential to be a noninvasive imaging tool for both basic neuroscience research in laboratories and clinical applications in neonatal intensive care units.
Original language | English |
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Article number | e202000366 |
Journal | Journal of Biophotonics |
Volume | 14 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2021 |
Bibliographical note
Funding Information:American Heart Association, Grant/Award Numbers: #14SDG20480186, #16GRNT30820006; National Institutes of Health, Grant/Award Numbers: COBRE #1P20GM121327, R01‐EB028792, R01‐HD101508‐01, R21‐AG046762, R21‐HD091118, R21‐NS114771; National Science Foundation, Grant/Award Number: #1539068; University of Kentucky Neuroscience Research Priority Area (NRPA) Pilot Grant Funding information
Funding Information:
This work was supported by the National Institutes of Health (NIH, R01‐HD101508‐01, R01‐EB028792, R21‐HD091118, R21‐AG046762, R21‐NS114771 and COBRE #1P20GM121327), American Heart Association (AHA #16GRNT30820006 and #14SDG20480186), National Science Foundation (NSF #1539068), and a University of Kentucky Neuroscience Research Priority Area (NRPA) Pilot Grant. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, AHA, NSF, or NRPA.
Publisher Copyright:
© 2020 Wiley-VCH GmbH
Keywords
- cerebral blood flow
- neonatal piglet
- optical imaging
- perinatal disease
ASJC Scopus subject areas
- Chemistry (all)
- Materials Science (all)
- Biochemistry, Genetics and Molecular Biology (all)
- Engineering (all)
- Physics and Astronomy (all)