Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets

Chong Huang; Siavash Mazdeyasna; Mehrana Mohtasebi; Kathryn E. Saatman; Qiang Cheng; Guoqiang Yu; Lei Chen

doi:10.1002/jbio.202000366

Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets

Chong Huang, Siavash Mazdeyasna, Mehrana Mohtasebi, Kathryn E. Saatman, Qiang Cheng, Guoqiang Yu, Lei Chen

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We adapted and tested an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) system for 3D imaging of cerebral blood flow (CBF) variations in perinatal disease models utilizing neonatal piglets, which closely resemble human neonates. CBF variations were concurrently measured by the scDCT and an established diffuse correlation spectroscopy (DCS) during global ischemia, intraventricular hemorrhage, and asphyxia; significant correlations were observed. Moreover, CBF variations associated reasonably with vital pathophysiological changes. In contrast to DCS measurements of mixed signals from local scalp, skull and brain, scDCT generates 3D images of CBF distributions at prescribed depths within the head, thus enabling specific determination of regional cerebral ischemia. With further optimization and validation in animals and human neonates, scDCT has the potential to be a noninvasive imaging tool for both basic neuroscience research in laboratories and clinical applications in neonatal intensive care units.

Original language	English
Article number	e202000366
Journal	Journal of Biophotonics
Volume	14
Issue number	4
DOIs	https://doi.org/10.1002/jbio.202000366
State	Published - Apr 2021

Bibliographical note

Funding Information:
American Heart Association, Grant/Award Numbers: #14SDG20480186, #16GRNT30820006; National Institutes of Health, Grant/Award Numbers: COBRE #1P20GM121327, R01‐EB028792, R01‐HD101508‐01, R21‐AG046762, R21‐HD091118, R21‐NS114771; National Science Foundation, Grant/Award Number: #1539068; University of Kentucky Neuroscience Research Priority Area (NRPA) Pilot Grant Funding information

Funding Information:
This work was supported by the National Institutes of Health (NIH, R01‐HD101508‐01, R01‐EB028792, R21‐HD091118, R21‐AG046762, R21‐NS114771 and COBRE #1P20GM121327), American Heart Association (AHA #16GRNT30820006 and #14SDG20480186), National Science Foundation (NSF #1539068), and a University of Kentucky Neuroscience Research Priority Area (NRPA) Pilot Grant. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, AHA, NSF, or NRPA.

Publisher Copyright:
© 2020 Wiley-VCH GmbH

Keywords

cerebral blood flow
neonatal piglet
optical imaging
perinatal disease

ASJC Scopus subject areas

Chemistry (all)
Materials Science (all)
Biochemistry, Genetics and Molecular Biology (all)
Engineering (all)
Physics and Astronomy (all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jbio.202000366

Cite this

@article{c427f56f63884562aadcc6b7064c306d,

title = "Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets",

abstract = "We adapted and tested an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) system for 3D imaging of cerebral blood flow (CBF) variations in perinatal disease models utilizing neonatal piglets, which closely resemble human neonates. CBF variations were concurrently measured by the scDCT and an established diffuse correlation spectroscopy (DCS) during global ischemia, intraventricular hemorrhage, and asphyxia; significant correlations were observed. Moreover, CBF variations associated reasonably with vital pathophysiological changes. In contrast to DCS measurements of mixed signals from local scalp, skull and brain, scDCT generates 3D images of CBF distributions at prescribed depths within the head, thus enabling specific determination of regional cerebral ischemia. With further optimization and validation in animals and human neonates, scDCT has the potential to be a noninvasive imaging tool for both basic neuroscience research in laboratories and clinical applications in neonatal intensive care units.",

keywords = "cerebral blood flow, neonatal piglet, optical imaging, perinatal disease",

author = "Chong Huang and Siavash Mazdeyasna and Mehrana Mohtasebi and Saatman, {Kathryn E.} and Qiang Cheng and Guoqiang Yu and Lei Chen",

note = "Funding Information: American Heart Association, Grant/Award Numbers: #14SDG20480186, #16GRNT30820006; National Institutes of Health, Grant/Award Numbers: COBRE #1P20GM121327, R01‐EB028792, R01‐HD101508‐01, R21‐AG046762, R21‐HD091118, R21‐NS114771; National Science Foundation, Grant/Award Number: #1539068; University of Kentucky Neuroscience Research Priority Area (NRPA) Pilot Grant Funding information Funding Information: This work was supported by the National Institutes of Health (NIH, R01‐HD101508‐01, R01‐EB028792, R21‐HD091118, R21‐AG046762, R21‐NS114771 and COBRE #1P20GM121327), American Heart Association (AHA #16GRNT30820006 and #14SDG20480186), National Science Foundation (NSF #1539068), and a University of Kentucky Neuroscience Research Priority Area (NRPA) Pilot Grant. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, AHA, NSF, or NRPA. Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH",

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doi = "10.1002/jbio.202000366",

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AU - Mazdeyasna, Siavash

AU - Mohtasebi, Mehrana

AU - Saatman, Kathryn E.

AU - Cheng, Qiang

AU - Yu, Guoqiang

AU - Chen, Lei

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Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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