Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets

Chong Huang; Siavash Mazdeyasna; Mehrana Mohtasebi; Kathryn E. Saatman; Qiang Cheng; Guoqiang Yu; Lei Chen

doi:10.1002/jbio.202000366

Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets

Chong Huang
, Siavash Mazdeyasna
, Mehrana Mohtasebi
, Kathryn E. Saatman
, Qiang Cheng
, Guoqiang Yu
, Lei Chen

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We adapted and tested an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) system for 3D imaging of cerebral blood flow (CBF) variations in perinatal disease models utilizing neonatal piglets, which closely resemble human neonates. CBF variations were concurrently measured by the scDCT and an established diffuse correlation spectroscopy (DCS) during global ischemia, intraventricular hemorrhage, and asphyxia; significant correlations were observed. Moreover, CBF variations associated reasonably with vital pathophysiological changes. In contrast to DCS measurements of mixed signals from local scalp, skull and brain, scDCT generates 3D images of CBF distributions at prescribed depths within the head, thus enabling specific determination of regional cerebral ischemia. With further optimization and validation in animals and human neonates, scDCT has the potential to be a noninvasive imaging tool for both basic neuroscience research in laboratories and clinical applications in neonatal intensive care units.

Original language	English
Article number	e202000366
Journal	Journal of Biophotonics
Volume	14
Issue number	4
DOIs	https://doi.org/10.1002/jbio.202000366
State	Published - Apr 2021

Bibliographical note

Publisher Copyright:
© 2020 Wiley-VCH GmbH

Funding

American Heart Association, Grant/Award Numbers: #14SDG20480186, #16GRNT30820006; National Institutes of Health, Grant/Award Numbers: COBRE #1P20GM121327, R01‐EB028792, R01‐HD101508‐01, R21‐AG046762, R21‐HD091118, R21‐NS114771; National Science Foundation, Grant/Award Number: #1539068; University of Kentucky Neuroscience Research Priority Area (NRPA) Pilot Grant Funding information This work was supported by the National Institutes of Health (NIH, R01‐HD101508‐01, R01‐EB028792, R21‐HD091118, R21‐AG046762, R21‐NS114771 and COBRE #1P20GM121327), American Heart Association (AHA #16GRNT30820006 and #14SDG20480186), National Science Foundation (NSF #1539068), and a University of Kentucky Neuroscience Research Priority Area (NRPA) Pilot Grant. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, AHA, NSF, or NRPA.

Funders	Funder number
CEPR COBRE	1P20GM121327
NRPA
University of Kentucky Neuroscience Research Priority Area
National Science Foundation Arctic Social Science Program	1539068
National Institutes of Health (NIH)	R21‐NS114771, R01‐EB028792, R21‐AG046762, R21‐HD091118
NIH National Institute of Child Health and Human Development National Center for Medical Rehabilitation Research	R01HD101508
American the American Heart Association	16GRNT30820006, 14SDG20480186
Boehringer Ingelheim Animal Health Australia Pty. Ltd

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cerebral blood flow
neonatal piglet
optical imaging
perinatal disease

ASJC Scopus subject areas

General Chemistry
General Materials Science
General Biochemistry, Genetics and Molecular Biology
General Engineering
General Physics and Astronomy

Access to Document

10.1002/jbio.202000366

Cite this

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title = "Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets",

abstract = "We adapted and tested an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) system for 3D imaging of cerebral blood flow (CBF) variations in perinatal disease models utilizing neonatal piglets, which closely resemble human neonates. CBF variations were concurrently measured by the scDCT and an established diffuse correlation spectroscopy (DCS) during global ischemia, intraventricular hemorrhage, and asphyxia; significant correlations were observed. Moreover, CBF variations associated reasonably with vital pathophysiological changes. In contrast to DCS measurements of mixed signals from local scalp, skull and brain, scDCT generates 3D images of CBF distributions at prescribed depths within the head, thus enabling specific determination of regional cerebral ischemia. With further optimization and validation in animals and human neonates, scDCT has the potential to be a noninvasive imaging tool for both basic neuroscience research in laboratories and clinical applications in neonatal intensive care units.",

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author = "Chong Huang and Siavash Mazdeyasna and Mehrana Mohtasebi and Saatman, \{Kathryn E.\} and Qiang Cheng and Guoqiang Yu and Lei Chen",

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language = "English",

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AU - Huang, Chong

AU - Mazdeyasna, Siavash

AU - Mohtasebi, Mehrana

AU - Saatman, Kathryn E.

AU - Cheng, Qiang

AU - Yu, Guoqiang

AU - Chen, Lei

PY - 2021/4

Y1 - 2021/4

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KW - cerebral blood flow

KW - neonatal piglet

KW - optical imaging

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Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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