Spectral peak-shift estimation with wavelength dependent sources and detectors

Research output: Contribution to journalArticlepeer-review


This correspondence extends Karl and Pien's ["High-Resolution Biosensor Spectral Peak Shift Estimation,"IEEE Transactions on Signal Processing, vol 53, no. 12, pp. 4631-4639, December 2005] approach to spectral-shift estimation for optical sensors to account for wavelength dependent illumination sources and detectors. Relaxing the assumption of spectrally uniform source power and detector efficiency alters the previously derived Cramér-Rao bound and maximum-likelihood estimator. The new estimator offers significantly reduced error compared to the wavelength invariant estimator and common ad hoc estimators.

Original languageEnglish
Pages (from-to)5269-5272
Number of pages4
JournalIEEE Transactions on Signal Processing
Issue number10 II
StatePublished - 2008

Bibliographical note

Funding Information:
Manuscript received January 2, 2008; revised June 21, 2008. First published July 25, 2008; current version published September 17, 2008. The associate editor coordinating the review of this manuscript and approving it for publication was Dr. Tryphon T. Georgiou. This material is based upon work supported by the National Science Foundation under Grant 0716486.


  • Cramér-Rao lower bound
  • Optical sensors
  • Spectral peakshift estimation

ASJC Scopus subject areas

  • Signal Processing
  • Electrical and Electronic Engineering


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