Abstract
A near-infrared (IR) spectrophotometer, integrating optics, and parallel-vector supercomputer are employed to develop a mathematical model that predicts the dissolution rate of individual intact tablets from near-IR spectra (r2 = 0.985). Each tablet can be analyzed nondestructively by the spectrophotometer in less than 1 min. The model permits hundreds of near-IR wavelengths to be used in the determination of dissolution rate, leading to increased accuracy.
Original language | English |
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Pages (from-to) | 974-978 |
Number of pages | 5 |
Journal | Pharmaceutical Research |
Volume | 8 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1991 |
Keywords
- degradation product
- dissolution rate
- intact tablets
- moisture effects
- near-infrared (IR)
ASJC Scopus subject areas
- Biotechnology
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Organic Chemistry
- Pharmacology (medical)