Spectrophotometric Prediction of the Dissolution Rate of Carbamazepine Tablets

Peter N. Zannikos, Wen I. Li, James K. Drennen, Robert A. Lodder

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


A near-infrared (IR) spectrophotometer, integrating optics, and parallel-vector supercomputer are employed to develop a mathematical model that predicts the dissolution rate of individual intact tablets from near-IR spectra (r2 = 0.985). Each tablet can be analyzed nondestructively by the spectrophotometer in less than 1 min. The model permits hundreds of near-IR wavelengths to be used in the determination of dissolution rate, leading to increased accuracy.

Original languageEnglish
Pages (from-to)974-978
Number of pages5
JournalPharmaceutical Research
Issue number8
StatePublished - Aug 1991


  • degradation product
  • dissolution rate
  • intact tablets
  • moisture effects
  • near-infrared (IR)

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)


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