Spectrophotometric Prediction of the Dissolution Rate of Carbamazepine Tablets

Peter N. Zannikos; Wen I. Li; James K. Drennen; Robert A. Lodder

doi:10.1023/A:1015840604423

Spectrophotometric Prediction of the Dissolution Rate of Carbamazepine Tablets

Peter N. Zannikos, Wen I. Li, James K. Drennen, Robert A. Lodder

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

A near-infrared (IR) spectrophotometer, integrating optics, and parallel-vector supercomputer are employed to develop a mathematical model that predicts the dissolution rate of individual intact tablets from near-IR spectra (r² = 0.985). Each tablet can be analyzed nondestructively by the spectrophotometer in less than 1 min. The model permits hundreds of near-IR wavelengths to be used in the determination of dissolution rate, leading to increased accuracy.

Original language	English
Pages (from-to)	974-978
Number of pages	5
Journal	Pharmaceutical Research
Volume	8
Issue number	8
DOIs	https://doi.org/10.1023/A:1015840604423
State	Published - Aug 1991

Keywords

degradation product
dissolution rate
intact tablets
moisture effects
near-infrared (IR)

ASJC Scopus subject areas

Biotechnology
Molecular Medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry
Pharmacology (medical)

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10.1023/A:1015840604423

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abstract = "A near-infrared (IR) spectrophotometer, integrating optics, and parallel-vector supercomputer are employed to develop a mathematical model that predicts the dissolution rate of individual intact tablets from near-IR spectra (r2 = 0.985). Each tablet can be analyzed nondestructively by the spectrophotometer in less than 1 min. The model permits hundreds of near-IR wavelengths to be used in the determination of dissolution rate, leading to increased accuracy.",

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author = "Zannikos, {Peter N.} and Li, {Wen I.} and Drennen, {James K.} and Lodder, {Robert A.}",

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language = "English",

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AU - Zannikos, Peter N.

AU - Li, Wen I.

AU - Drennen, James K.

AU - Lodder, Robert A.

PY - 1991/8

Y1 - 1991/8

N2 - A near-infrared (IR) spectrophotometer, integrating optics, and parallel-vector supercomputer are employed to develop a mathematical model that predicts the dissolution rate of individual intact tablets from near-IR spectra (r2 = 0.985). Each tablet can be analyzed nondestructively by the spectrophotometer in less than 1 min. The model permits hundreds of near-IR wavelengths to be used in the determination of dissolution rate, leading to increased accuracy.

AB - A near-infrared (IR) spectrophotometer, integrating optics, and parallel-vector supercomputer are employed to develop a mathematical model that predicts the dissolution rate of individual intact tablets from near-IR spectra (r2 = 0.985). Each tablet can be analyzed nondestructively by the spectrophotometer in less than 1 min. The model permits hundreds of near-IR wavelengths to be used in the determination of dissolution rate, leading to increased accuracy.

KW - degradation product

KW - dissolution rate

KW - intact tablets

KW - moisture effects

KW - near-infrared (IR)

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EP - 978

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 8

ER -

Spectrophotometric Prediction of the Dissolution Rate of Carbamazepine Tablets

Abstract

Keywords

ASJC Scopus subject areas

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