Spectrophotometric Prediction of the Dissolution Rate of Carbamazepine Tablets

Peter N. Zannikos; Wen I. Li; James K. Drennen; Robert A. Lodder

doi:10.1023/A:1015840604423

Spectrophotometric Prediction of the Dissolution Rate of Carbamazepine Tablets

Peter N. Zannikos, Wen I. Li, James K. Drennen, Robert A. Lodder

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

A near-infrared (IR) spectrophotometer, integrating optics, and parallel-vector supercomputer are employed to develop a mathematical model that predicts the dissolution rate of individual intact tablets from near-IR spectra (r² = 0.985). Each tablet can be analyzed nondestructively by the spectrophotometer in less than 1 min. The model permits hundreds of near-IR wavelengths to be used in the determination of dissolution rate, leading to increased accuracy.

Original language	English
Pages (from-to)	974-978
Number of pages	5
Journal	Pharmaceutical Research
Volume	8
Issue number	8
DOIs	https://doi.org/10.1023/A:1015840604423
State	Published - Aug 1991

Keywords

degradation product
dissolution rate
intact tablets
moisture effects
near-infrared (IR)

ASJC Scopus subject areas

Biotechnology
Molecular Medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry
Pharmacology (medical)

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abstract = "A near-infrared (IR) spectrophotometer, integrating optics, and parallel-vector supercomputer are employed to develop a mathematical model that predicts the dissolution rate of individual intact tablets from near-IR spectra (r2 = 0.985). Each tablet can be analyzed nondestructively by the spectrophotometer in less than 1 min. The model permits hundreds of near-IR wavelengths to be used in the determination of dissolution rate, leading to increased accuracy.",

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AU - Drennen, James K.

AU - Lodder, Robert A.

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N2 - A near-infrared (IR) spectrophotometer, integrating optics, and parallel-vector supercomputer are employed to develop a mathematical model that predicts the dissolution rate of individual intact tablets from near-IR spectra (r2 = 0.985). Each tablet can be analyzed nondestructively by the spectrophotometer in less than 1 min. The model permits hundreds of near-IR wavelengths to be used in the determination of dissolution rate, leading to increased accuracy.

AB - A near-infrared (IR) spectrophotometer, integrating optics, and parallel-vector supercomputer are employed to develop a mathematical model that predicts the dissolution rate of individual intact tablets from near-IR spectra (r2 = 0.985). Each tablet can be analyzed nondestructively by the spectrophotometer in less than 1 min. The model permits hundreds of near-IR wavelengths to be used in the determination of dissolution rate, leading to increased accuracy.

KW - degradation product

KW - dissolution rate

KW - intact tablets

KW - moisture effects

KW - near-infrared (IR)

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Spectrophotometric Prediction of the Dissolution Rate of Carbamazepine Tablets

Abstract

Keywords

ASJC Scopus subject areas

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