Sphingolipids and their enigmatic role in asthma

Jamie L. Sturgill

doi:10.1016/j.jbior.2018.09.001

Sphingolipids and their enigmatic role in asthma

Jamie L. Sturgill

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Asthma is defined as a chronic inflammatory condition in the lung and is characterized by episodic shortness of breath with expiratory wheezing and cough. Asthma is a serious public health concern globally with an estimated incidence over 300 million. Asthma is a complex disease in that it manifests as disease of gene and environmental interactions. Sphingolipids are a unique class of lipids involved in a host of biological functions ranging from serving as key cellular membrane lipids to acting as critical signaling molecules. To date sphingolipids have been studied across various human conditions ranging from neurological disorders to cancer to infection to autoimmunity. This review will focus on the role of sphingolipids in asthma development and pathology with particular focus on the role of mast cell sphingolipid biology.

Original language	English
Pages (from-to)	74-81
Number of pages	8
Journal	Advances in Biological Regulation
Volume	70
DOIs	https://doi.org/10.1016/j.jbior.2018.09.001
State	Published - Dec 2018

Bibliographical note

Publisher Copyright:
© 2018 The Author

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors for the compilation of this review article. This research is supported by National Institutes of Health grant R01AI50094 awarded to Sarah Spiegel.

Funders

Funder number

National Institutes of Health (NIH)

National Institute of Allergy and Infectious F32-AI286447 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R01AI168214 Jason W. Rosch Diseases National Institute of Allergy and Infectious P30 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R00-AI166116 Christopher D. Radka Diseases National Institute of Allergy and Infectious T32-AI106700 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R01AI192221 Jason W. Rosch Diseases National Inst...

R01AI125433, R01AI050094

Keywords

Asthma
Mast cell
Sphingolipid

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jbior.2018.09.001

Cite this

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abstract = "Asthma is defined as a chronic inflammatory condition in the lung and is characterized by episodic shortness of breath with expiratory wheezing and cough. Asthma is a serious public health concern globally with an estimated incidence over 300 million. Asthma is a complex disease in that it manifests as disease of gene and environmental interactions. Sphingolipids are a unique class of lipids involved in a host of biological functions ranging from serving as key cellular membrane lipids to acting as critical signaling molecules. To date sphingolipids have been studied across various human conditions ranging from neurological disorders to cancer to infection to autoimmunity. This review will focus on the role of sphingolipids in asthma development and pathology with particular focus on the role of mast cell sphingolipid biology.",

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AB - Asthma is defined as a chronic inflammatory condition in the lung and is characterized by episodic shortness of breath with expiratory wheezing and cough. Asthma is a serious public health concern globally with an estimated incidence over 300 million. Asthma is a complex disease in that it manifests as disease of gene and environmental interactions. Sphingolipids are a unique class of lipids involved in a host of biological functions ranging from serving as key cellular membrane lipids to acting as critical signaling molecules. To date sphingolipids have been studied across various human conditions ranging from neurological disorders to cancer to infection to autoimmunity. This review will focus on the role of sphingolipids in asthma development and pathology with particular focus on the role of mast cell sphingolipid biology.

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KW - Sphingolipid

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ER -

Sphingolipids and their enigmatic role in asthma

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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