Spin label study of erythrocyte membrane fluidity in myotonic and Duchenne muscular dystrophy and congenital myotonia

D. Allan Butterfield; D. B. Chesnut; Stanley H. Appel; Allen D. Roses

doi:10.1038/263159a0

Spin label study of erythrocyte membrane fluidity in myotonic and Duchenne muscular dystrophy and congenital myotonia

D. Allan Butterfield
, D. B. Chesnut
, Stanley H. Appel
, Allen D. Roses

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

INTACT erythrocyte membranes from patients with myotonic muscular dystrophy (MMD) have been shown by spin labelling (review of method in ref. 1) to have greater membrane surface fluidity than normal^2,3. We have now evaluated the specificity of this phenomenon. We used erythrocytes from patients with MMD, and also from patients with Duchenne muscular dystrophy (DMD), as a model of dystrophy with no myotonia, and from patients with congenital myotonia (CM) as a model of myotonia without dystrophy.

Original language	English
Pages (from-to)	159-161
Number of pages	3
Journal	Nature
Volume	263
Issue number	5573
DOIs	https://doi.org/10.1038/263159a0
State	Published - 1976

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title = "Spin label study of erythrocyte membrane fluidity in myotonic and Duchenne muscular dystrophy and congenital myotonia",

abstract = "INTACT erythrocyte membranes from patients with myotonic muscular dystrophy (MMD) have been shown by spin labelling (review of method in ref. 1) to have greater membrane surface fluidity than normal2,3. We have now evaluated the specificity of this phenomenon. We used erythrocytes from patients with MMD, and also from patients with Duchenne muscular dystrophy (DMD), as a model of dystrophy with no myotonia, and from patients with congenital myotonia (CM) as a model of myotonia without dystrophy.",

author = "Butterfield, \{D. Allan\} and Chesnut, \{D. B.\} and Appel, \{Stanley H.\} and Roses, \{Allen D.\}",

year = "1976",

doi = "10.1038/263159a0",

language = "English",

volume = "263",

pages = "159--161",

number = "5573",

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T1 - Spin label study of erythrocyte membrane fluidity in myotonic and Duchenne muscular dystrophy and congenital myotonia

AU - Butterfield, D. Allan

AU - Chesnut, D. B.

AU - Appel, Stanley H.

AU - Roses, Allen D.

PY - 1976

Y1 - 1976

N2 - INTACT erythrocyte membranes from patients with myotonic muscular dystrophy (MMD) have been shown by spin labelling (review of method in ref. 1) to have greater membrane surface fluidity than normal2,3. We have now evaluated the specificity of this phenomenon. We used erythrocytes from patients with MMD, and also from patients with Duchenne muscular dystrophy (DMD), as a model of dystrophy with no myotonia, and from patients with congenital myotonia (CM) as a model of myotonia without dystrophy.

AB - INTACT erythrocyte membranes from patients with myotonic muscular dystrophy (MMD) have been shown by spin labelling (review of method in ref. 1) to have greater membrane surface fluidity than normal2,3. We have now evaluated the specificity of this phenomenon. We used erythrocytes from patients with MMD, and also from patients with Duchenne muscular dystrophy (DMD), as a model of dystrophy with no myotonia, and from patients with congenital myotonia (CM) as a model of myotonia without dystrophy.

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UR - https://www.scopus.com/pages/publications/0017189010#tab=citedBy

U2 - 10.1038/263159a0

DO - 10.1038/263159a0

M3 - Article

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EP - 161

JO - Nature

JF - Nature

IS - 5573

ER -

Spin label study of erythrocyte membrane fluidity in myotonic and Duchenne muscular dystrophy and congenital myotonia

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