Spinal cord compression due to extramedullary hematopoiesis in thalassemia: Long-term follow-up after radiotherapy

Don V. Jackson; Marcus E. Randall; Frederick Richards

doi:10.1016/0090-3019(88)90047-X

Spinal cord compression due to extramedullary hematopoiesis in thalassemia: Long-term follow-up after radiotherapy

Don V. Jackson, Marcus E. Randall, Frederick Richards

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Abstract

Spinal cord compression as a consequence of mass lesions due to extramedullary hematopoiesis is a well-described but rare syndrome occurring in thalassemia and some other hematologic conditions. After low-dose radiotherapy alone, a rapid and durable response occurred in a patient with thalassemia. No side effects were encountered and the patient has been stable neurologically for over 7 years since treatment. The results of the current case, and those previously reported in which radiotherapy alone was given, suggest that low-dose radiotherapy should be considered as a primary treatment modality for the management of this syndrome, at least in patients with thalassemia.

Original language	English
Pages (from-to)	389-392
Number of pages	4
Journal	Surgical Neurology
Volume	29
Issue number	5
DOIs	https://doi.org/10.1016/0090-3019(88)90047-X
State	Published - May 1988

Bibliographical note

Funding Information:
The authorsw ish to thank Mrs. Jane Moye for manuscripptr epara-tion. This study was supportedin part by grant CA-12197 from the National Instituteso f Health.

Keywords

Cord compression
Extramedullary hematopoiesis
Radiation therapy
Thalassemia

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1016/0090-3019(88)90047-X

Cite this

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title = "Spinal cord compression due to extramedullary hematopoiesis in thalassemia: Long-term follow-up after radiotherapy",

abstract = "Spinal cord compression as a consequence of mass lesions due to extramedullary hematopoiesis is a well-described but rare syndrome occurring in thalassemia and some other hematologic conditions. After low-dose radiotherapy alone, a rapid and durable response occurred in a patient with thalassemia. No side effects were encountered and the patient has been stable neurologically for over 7 years since treatment. The results of the current case, and those previously reported in which radiotherapy alone was given, suggest that low-dose radiotherapy should be considered as a primary treatment modality for the management of this syndrome, at least in patients with thalassemia.",

keywords = "Cord compression, Extramedullary hematopoiesis, Radiation therapy, Thalassemia",

author = "Jackson, {Don V.} and Randall, {Marcus E.} and Frederick Richards",

note = "Funding Information: The authorsw ish to thank Mrs. Jane Moye for manuscripptr epara-tion. This study was supportedin part by grant CA-12197 from the National Instituteso f Health.",

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doi = "10.1016/0090-3019(88)90047-X",

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volume = "29",

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T1 - Spinal cord compression due to extramedullary hematopoiesis in thalassemia

T2 - Long-term follow-up after radiotherapy

AU - Jackson, Don V.

AU - Randall, Marcus E.

AU - Richards, Frederick

N1 - Funding Information: The authorsw ish to thank Mrs. Jane Moye for manuscripptr epara-tion. This study was supportedin part by grant CA-12197 from the National Instituteso f Health.

PY - 1988/5

Y1 - 1988/5

N2 - Spinal cord compression as a consequence of mass lesions due to extramedullary hematopoiesis is a well-described but rare syndrome occurring in thalassemia and some other hematologic conditions. After low-dose radiotherapy alone, a rapid and durable response occurred in a patient with thalassemia. No side effects were encountered and the patient has been stable neurologically for over 7 years since treatment. The results of the current case, and those previously reported in which radiotherapy alone was given, suggest that low-dose radiotherapy should be considered as a primary treatment modality for the management of this syndrome, at least in patients with thalassemia.

AB - Spinal cord compression as a consequence of mass lesions due to extramedullary hematopoiesis is a well-described but rare syndrome occurring in thalassemia and some other hematologic conditions. After low-dose radiotherapy alone, a rapid and durable response occurred in a patient with thalassemia. No side effects were encountered and the patient has been stable neurologically for over 7 years since treatment. The results of the current case, and those previously reported in which radiotherapy alone was given, suggest that low-dose radiotherapy should be considered as a primary treatment modality for the management of this syndrome, at least in patients with thalassemia.

KW - Cord compression

KW - Extramedullary hematopoiesis

KW - Radiation therapy

KW - Thalassemia

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Spinal cord compression due to extramedullary hematopoiesis in thalassemia: Long-term follow-up after radiotherapy

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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