Spinal cord compression due to extramedullary hematopoiesis in thalassemia: Long-term follow-up after radiotherapy

Don V. Jackson, Marcus E. Randall, Frederick Richards

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Spinal cord compression as a consequence of mass lesions due to extramedullary hematopoiesis is a well-described but rare syndrome occurring in thalassemia and some other hematologic conditions. After low-dose radiotherapy alone, a rapid and durable response occurred in a patient with thalassemia. No side effects were encountered and the patient has been stable neurologically for over 7 years since treatment. The results of the current case, and those previously reported in which radiotherapy alone was given, suggest that low-dose radiotherapy should be considered as a primary treatment modality for the management of this syndrome, at least in patients with thalassemia.

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalSurgical Neurology
Volume29
Issue number5
DOIs
StatePublished - May 1988

Bibliographical note

Funding Information:
The authorsw ish to thank Mrs. Jane Moye for manuscripptr epara-tion. This study was supportedin part by grant CA-12197 from the National Instituteso f Health.

Keywords

  • Cord compression
  • Extramedullary hematopoiesis
  • Radiation therapy
  • Thalassemia

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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