Spinal cord motoneurons express p75NGFR and p145trkB mRNA in amyotrophic lateral sclerosis

Jeffrey L. Seeburger; Seth Tarras; Howard Natter; Joe E. Springer

doi:10.1016/0006-8993(93)90304-6

Spinal cord motoneurons express p75^NGFR and p145^trkB mRNA in amyotrophic lateral sclerosis

Jeffrey L. Seeburger, Seth Tarras, Howard Natter, Joe E. Springer

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

In the present study, in situ hybridization was used to examine the expression of nerve growth factor (NGF) receptor (p75^NGFR), trk (p140^trk) and trkB (p145^trkB) mRNA in spinal cord sections from patients with amyotrophic lateral sclerosis (ALS). We report that the expression of p75^NGFR and p145^trkB mRNA is elevated in alpha motoneurons in ALS sections. However, p140^trk mRNA was not expressed in either ALS or control sections.

Original language	English
Pages (from-to)	111-115
Number of pages	5
Journal	Brain Research
Volume	621
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(93)90304-6
State	Published - Sep 3 1993

Bibliographical note

Funding Information:
We thank the local ALS chapter, the Hahnemann ALS clinic and Dr. Christos Katsetos for their support, Dr. Timothy Cope for a critical review of the manuscript, and Antony Gray for technical assistance. We would also like to thank Drs. E. Shooter for the p75 NGFR cDNA and L. Parada for the p140 trk cDNA. The p145 trkn was obtained from the American Tissue Culture Collection. This work was supported by PHS Grant NS30248 and the local Greater Philadelphia ALS Chapter (J.E.S.).

Keywords

Alpha motoneuron
Degeneration
In situ hybridization
Motor neuron disease
Neurotrophin
Trk

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(93)90304-6

Cite this

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title = "Spinal cord motoneurons express p75NGFR and p145trkB mRNA in amyotrophic lateral sclerosis",

abstract = "In the present study, in situ hybridization was used to examine the expression of nerve growth factor (NGF) receptor (p75NGFR), trk (p140trk) and trkB (p145trkB) mRNA in spinal cord sections from patients with amyotrophic lateral sclerosis (ALS). We report that the expression of p75NGFR and p145trkB mRNA is elevated in alpha motoneurons in ALS sections. However, p140trk mRNA was not expressed in either ALS or control sections.",

keywords = "Alpha motoneuron, Degeneration, In situ hybridization, Motor neuron disease, Neurotrophin, Trk",

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note = "Funding Information: We thank the local ALS chapter, the Hahnemann ALS clinic and Dr. Christos Katsetos for their support, Dr. Timothy Cope for a critical review of the manuscript, and Antony Gray for technical assistance. We would also like to thank Drs. E. Shooter for the p75 NGFR cDNA and L. Parada for the p140 trk cDNA. The p145 trkn was obtained from the American Tissue Culture Collection. This work was supported by PHS Grant NS30248 and the local Greater Philadelphia ALS Chapter (J.E.S.).",

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AU - Tarras, Seth

AU - Natter, Howard

AU - Springer, Joe E.

N1 - Funding Information: We thank the local ALS chapter, the Hahnemann ALS clinic and Dr. Christos Katsetos for their support, Dr. Timothy Cope for a critical review of the manuscript, and Antony Gray for technical assistance. We would also like to thank Drs. E. Shooter for the p75 NGFR cDNA and L. Parada for the p140 trk cDNA. The p145 trkn was obtained from the American Tissue Culture Collection. This work was supported by PHS Grant NS30248 and the local Greater Philadelphia ALS Chapter (J.E.S.).

PY - 1993/9/3

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N2 - In the present study, in situ hybridization was used to examine the expression of nerve growth factor (NGF) receptor (p75NGFR), trk (p140trk) and trkB (p145trkB) mRNA in spinal cord sections from patients with amyotrophic lateral sclerosis (ALS). We report that the expression of p75NGFR and p145trkB mRNA is elevated in alpha motoneurons in ALS sections. However, p140trk mRNA was not expressed in either ALS or control sections.

AB - In the present study, in situ hybridization was used to examine the expression of nerve growth factor (NGF) receptor (p75NGFR), trk (p140trk) and trkB (p145trkB) mRNA in spinal cord sections from patients with amyotrophic lateral sclerosis (ALS). We report that the expression of p75NGFR and p145trkB mRNA is elevated in alpha motoneurons in ALS sections. However, p140trk mRNA was not expressed in either ALS or control sections.

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KW - Degeneration

KW - In situ hybridization

KW - Motor neuron disease

KW - Neurotrophin

KW - Trk

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