Spinal cord motoneurons express p75NGFR and p145trkB mRNA in amyotrophic lateral sclerosis

Jeffrey L. Seeburger, Seth Tarras, Howard Natter, Joe E. Springer

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


In the present study, in situ hybridization was used to examine the expression of nerve growth factor (NGF) receptor (p75NGFR), trk (p140trk) and trkB (p145trkB) mRNA in spinal cord sections from patients with amyotrophic lateral sclerosis (ALS). We report that the expression of p75NGFR and p145trkB mRNA is elevated in alpha motoneurons in ALS sections. However, p140trk mRNA was not expressed in either ALS or control sections.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalBrain Research
Issue number1
StatePublished - Sep 3 1993

Bibliographical note

Funding Information:
We thank the local ALS chapter, the Hahnemann ALS clinic and Dr. Christos Katsetos for their support, Dr. Timothy Cope for a critical review of the manuscript, and Antony Gray for technical assistance. We would also like to thank Drs. E. Shooter for the p75 NGFR cDNA and L. Parada for the p140 trk cDNA. The p145 trkn was obtained from the American Tissue Culture Collection. This work was supported by PHS Grant NS30248 and the local Greater Philadelphia ALS Chapter (J.E.S.).


  • Alpha motoneuron
  • Degeneration
  • In situ hybridization
  • Motor neuron disease
  • Neurotrophin
  • Trk

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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