Spontaneous fetal behavior after maternal exposure to ethanol

William P. Smotherman; Karen S. Woodruff; Scott R. Robinson; Carmen Del Real; Susan Barron; Edward P. Riley

doi:10.1016/0091-3057(86)90332-1

Spontaneous fetal behavior after maternal exposure to ethanol

William P. Smotherman, Karen S. Woodruff, Scott R. Robinson, Carmen Del Real, Susan Barron, Edward P. Riley

Psychology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Acute and chronic intubations of ethanol to pregnant rats produced changes in spontaneous fetal behavior four hours later. Fetuses from mothers in intermediate alcohol groups (4 and 6 g/kg) were substantially less active than controls (0 g/kg), but fetuses from low (2 g/kg) and high (8 g/kg) alcohol groups showed little indication of behavioral suppression. Circulating levels of alcohol in maternal blood, fetal homogenate and amniotic fluid at the time fetuses were observed confirmed that fetuses were exposed to alcohol in utero, but the measured concentrations of alcohol were not predictive of fetal activity. We suggest that some of the developmental consequences of Fetal Alcohol Syndrome may be the consequence of fetal inactivity induced by alcohol in utero.

Original language	English
Pages (from-to)	165-170
Number of pages	6
Journal	Pharmacology Biochemistry and Behavior
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/0091-3057(86)90332-1
State	Published - Feb 1986

Bibliographical note

Funding Information:
WPS IS supportedb y grant 16102-0f4r omthe NationalI nstltute of Chdd Healtha nd Human Developmen(Nt IH) and by grant3 0-262-0506fr om the ResearchC ouncilat OregonS tateUmverslty, NIH BiomedicaRl esearchS upportG rant RR07079 EPR is supported by grant 03249-07f rom the National Insmuteo f Alcohol Abuse and Alcohohsm We thank threea nonymourse viewersfo r provldmgh elpfuls uggestionms the preparatioonf this manuscript

Keywords

Alcohol
Behavioral pathogenesis
Dysmorphogenesis
Fetal Alcohol Syndrome
Fetal behavior
Pregnancy
Teratogen

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(86)90332-1

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title = "Spontaneous fetal behavior after maternal exposure to ethanol",

abstract = "Acute and chronic intubations of ethanol to pregnant rats produced changes in spontaneous fetal behavior four hours later. Fetuses from mothers in intermediate alcohol groups (4 and 6 g/kg) were substantially less active than controls (0 g/kg), but fetuses from low (2 g/kg) and high (8 g/kg) alcohol groups showed little indication of behavioral suppression. Circulating levels of alcohol in maternal blood, fetal homogenate and amniotic fluid at the time fetuses were observed confirmed that fetuses were exposed to alcohol in utero, but the measured concentrations of alcohol were not predictive of fetal activity. We suggest that some of the developmental consequences of Fetal Alcohol Syndrome may be the consequence of fetal inactivity induced by alcohol in utero.",

keywords = "Alcohol, Behavioral pathogenesis, Dysmorphogenesis, Fetal Alcohol Syndrome, Fetal behavior, Pregnancy, Teratogen",

author = "Smotherman, {William P.} and Woodruff, {Karen S.} and Robinson, {Scott R.} and {Del Real}, Carmen and Susan Barron and Riley, {Edward P.}",

note = "Funding Information: WPS IS supportedb y grant 16102-0f4r omthe NationalI nstltute of Chdd Healtha nd Human Developmen(Nt IH) and by grant3 0-262-0506fr om the ResearchC ouncilat OregonS tateUmverslty, NIH BiomedicaRl esearchS upportG rant RR07079 EPR is supported by grant 03249-07f rom the National Insmuteo f Alcohol Abuse and Alcohohsm We thank threea nonymourse viewersfo r provldmgh elpfuls uggestionms the preparatioonf this manuscript",

year = "1986",

month = feb,

doi = "10.1016/0091-3057(86)90332-1",

language = "English",

volume = "24",

pages = "165--170",

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T1 - Spontaneous fetal behavior after maternal exposure to ethanol

AU - Smotherman, William P.

AU - Woodruff, Karen S.

AU - Robinson, Scott R.

AU - Del Real, Carmen

AU - Barron, Susan

AU - Riley, Edward P.

N1 - Funding Information: WPS IS supportedb y grant 16102-0f4r omthe NationalI nstltute of Chdd Healtha nd Human Developmen(Nt IH) and by grant3 0-262-0506fr om the ResearchC ouncilat OregonS tateUmverslty, NIH BiomedicaRl esearchS upportG rant RR07079 EPR is supported by grant 03249-07f rom the National Insmuteo f Alcohol Abuse and Alcohohsm We thank threea nonymourse viewersfo r provldmgh elpfuls uggestionms the preparatioonf this manuscript

PY - 1986/2

Y1 - 1986/2

N2 - Acute and chronic intubations of ethanol to pregnant rats produced changes in spontaneous fetal behavior four hours later. Fetuses from mothers in intermediate alcohol groups (4 and 6 g/kg) were substantially less active than controls (0 g/kg), but fetuses from low (2 g/kg) and high (8 g/kg) alcohol groups showed little indication of behavioral suppression. Circulating levels of alcohol in maternal blood, fetal homogenate and amniotic fluid at the time fetuses were observed confirmed that fetuses were exposed to alcohol in utero, but the measured concentrations of alcohol were not predictive of fetal activity. We suggest that some of the developmental consequences of Fetal Alcohol Syndrome may be the consequence of fetal inactivity induced by alcohol in utero.

AB - Acute and chronic intubations of ethanol to pregnant rats produced changes in spontaneous fetal behavior four hours later. Fetuses from mothers in intermediate alcohol groups (4 and 6 g/kg) were substantially less active than controls (0 g/kg), but fetuses from low (2 g/kg) and high (8 g/kg) alcohol groups showed little indication of behavioral suppression. Circulating levels of alcohol in maternal blood, fetal homogenate and amniotic fluid at the time fetuses were observed confirmed that fetuses were exposed to alcohol in utero, but the measured concentrations of alcohol were not predictive of fetal activity. We suggest that some of the developmental consequences of Fetal Alcohol Syndrome may be the consequence of fetal inactivity induced by alcohol in utero.

KW - Alcohol

KW - Behavioral pathogenesis

KW - Dysmorphogenesis

KW - Fetal Alcohol Syndrome

KW - Fetal behavior

KW - Pregnancy

KW - Teratogen

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JO - Pharmacology Biochemistry and Behavior

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IS - 2

ER -

Spontaneous fetal behavior after maternal exposure to ethanol

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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