Spontaneous resolution of a single lesion of myeloid leukemia cutis in an infant: Case report and discussion

John A. D'Orazio, Joseph F. Pulliam, Jeffrey A. Moscow

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Though infantile leukemia has a historically poor prognosis, there may be a subset of patients with cutaneous disease whose disease will resolve without therapy. The authors report a case of infantile leukemia cutis who presented with a single subcutaneous chloroma that spontaneously resolved over the course of several weeks and who remains without evidence of disease nearly two years later. After reviewing the literature of congenital leukemia cutis, the authors conclude that withholding chemotherapy in infants with cutaneous myeloid leukemia in the absence of known negative prognostic factors (MLL or BCR-ABL translocations) or progressive disease is clinically indicated.

Original languageEnglish
Pages (from-to)457-468
Number of pages12
JournalPediatric Hematology and Oncology
Issue number5
StatePublished - Jun 2008

Bibliographical note

Funding Information:
This work was supported by the University of Kentucky and the Markey Cancer Center. The authors respectfully thank the family of our patient for allowing us to report clinical events and publish photographs detailing cutaneous findings in this case. We also thank Howard Weinstein (Massachusetts General Hospital) and Franklin Smith (Cincinnati Children’s Hospital Medical Center) for useful clinical discussion and management suggestions, Dermatopathology Associates (Pikeville, KY), the University of Louisville Department of Pathology for providing biopsy slides and interpretation of the initial skin biopsy, and Malinda Spry for photographic assistance. This case report and discussion meets with University of Kentucky IRB guidelines.


  • AML
  • Chemotherapy
  • Infantile leukemia
  • Leukemia cutis
  • Resolution

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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