Squishing, squeezing and stretching age hematopoietic stem cells

Chih Ling Wang; Mary Mohrin

doi:10.1038/s43587-025-01044-4

Squishing, squeezing and stretching age hematopoietic stem cells

Chih Ling Wang
, Mary Mohrin

Research output: Contribution to journal › Comment/debate

Abstract

Two recent studies, from Shang et al. and Mejía-Ramírez et al., identify complementary mechanical mechanisms that regulate hematopoietic stem cell aging: external shear stress and internal nuclear envelope tension. These forces represent an evolutionary tradeoff between immediate immune defense and long-term stem cell maintenance.

Original language	English
Pages (from-to)	29-31
Number of pages	3
Journal	Nature Aging
Volume	6
Issue number	1
DOIs	https://doi.org/10.1038/s43587-025-01044-4
State	Published - Jan 2026

Bibliographical note

Publisher Copyright:
© Springer Nature America, Inc. 2026.

Funding

Work in the Mohrin Lab is supported by a COBRE grant from NIGMS (P20GM121327), a NCI supported pilot grant from the Markey Cancer Center (MCC) and the Substance Use Priority Research Area (SUPRA), and administratively supported by NCI Cancer Center Support Grant (P30 CA177558).

Funders	Funder number
CEPR COBRE
National Childhood Cancer Registry – National Cancer Institute
National Institute of General Medical Sciences DP2GM119177 Sophie Dumont National Institute of General Medical Sciences	P20GM121327
University of Kentucky Markey Comprehensive Cancer Center	P30 CA177558

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Aging
Geriatrics and Gerontology

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abstract = "Two recent studies, from Shang et al. and Mej{\'i}a-Ram{\'i}rez et al., identify complementary mechanical mechanisms that regulate hematopoietic stem cell aging: external shear stress and internal nuclear envelope tension. These forces represent an evolutionary tradeoff between immediate immune defense and long-term stem cell maintenance.",

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Squishing, squeezing and stretching age hematopoietic stem cells

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

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