SR-BI selective lipid uptake: Subsequent metabolism of acute phase HDL

Maria C. De Beer, Nancy R. Webb, Nathan L. Whitaker, Joanne M. Wroblewski, Anisa Jahangiri, Deneys R. Van Der Westhuyzen, Frederick C. De Beer

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


OBJECTIVE-: The purpose of this study was to investigate the interaction of SAA and SR-BI in remodeling of acute phase HDL (AP HDL). METHODS AND RESULTS-: We used SAA and SR-BI adenoviral vector expression models to study the interaction between these entities. SR-BI processing of mouse AP HDL generated progressively smaller discreet HDL particles with distinct apolipoprotein compositions. SR-BI actions segregated apolipoproteins with the smallest particles containing only apoA-I. Larger remnants contained apoA-I, apoA-II, and SAA. Small apoA-I only particles failed to associate with preformed HDL, whereas larger remnants readily did. The presence of SAA on SR-BI-processed HDL particles propelled apoA-I to a small lipid-poor form and accelerated apoA-I catabolism. CONCLUSIONS-: Data indicate that after core and surface HDL lipid perturbation by SR-BI, SAA propels apoA-I to a small lipid-poor form while accelerating HDL metabolism.

Original languageEnglish
Pages (from-to)1298-1303
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number9
StatePublished - Sep 2009


  • HDL
  • Inflammation
  • Metabolism
  • SAA
  • SR-BI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'SR-BI selective lipid uptake: Subsequent metabolism of acute phase HDL'. Together they form a unique fingerprint.

Cite this