TY - JOUR
T1 - SREBP
T2 - A novel therapeutic target
AU - Xiao, Xu
AU - Song, Bao Liang
PY - 2013/1
Y1 - 2013/1
N2 - Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the biosynthesis of cholesterol, fatty acid, and triglyceride. They control the expression of crucial genes involved in lipogenesis and uptake. In this review, we summarize the processing of SREBPs and their regulation by insulin, cAMP, and vitamin A, and the relationship between miRNA and lipid metabolism. We also discuss the recent functional studies on SREBPs. These discoveries suggest that inhibition of SREBP can be a novel strategy to treat metabolic diseases, such as type II diabetes, insulin resistance, fatty liver, and atherosclerosis.
AB - Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the biosynthesis of cholesterol, fatty acid, and triglyceride. They control the expression of crucial genes involved in lipogenesis and uptake. In this review, we summarize the processing of SREBPs and their regulation by insulin, cAMP, and vitamin A, and the relationship between miRNA and lipid metabolism. We also discuss the recent functional studies on SREBPs. These discoveries suggest that inhibition of SREBP can be a novel strategy to treat metabolic diseases, such as type II diabetes, insulin resistance, fatty liver, and atherosclerosis.
KW - cAMP
KW - insulin
KW - miRNA
KW - SREBP
KW - therapeutic target
KW - vitamin A
UR - http://www.scopus.com/inward/record.url?scp=84871757651&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871757651&partnerID=8YFLogxK
U2 - 10.1093/abbs/gms112
DO - 10.1093/abbs/gms112
M3 - Review article
C2 - 23257291
AN - SCOPUS:84871757651
SN - 1672-9145
VL - 45
SP - 2
EP - 10
JO - Acta Biochimica et Biophysica Sinica
JF - Acta Biochimica et Biophysica Sinica
IS - 1
ER -
