Stability of nizatidine in total nutrient admixtures

J. Hatton, S. G. Holstad, A. D. Rosenbloom, T. Westrich, J. Hirsch

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The stability of nizatidine in total nutrient admixtures (TNAs) and the effect of the drug on the stability of lipid emulsions in the TNAs were studied. Duplicate 1476-mL amino acid-dextrose base solutions were prepared; nizatidine 300 mg was added to one. TNAs were prepared by adding to 75-mL samples of the base solutions Intralipid (KabiVitrum) or Liposyn II (Abbott) and sterile water is needed to achieve final lipid concentrations of 3% and 5%. Triplicate 100-mL samples for each lipid product and concentration were prepared; fat-free samples containing nizatidine were also studied. The theoretical final nizatidine concentration was 150 μg/mL. Samples were stored at 22 °C for 48 hours. Initially and at 12, 24, and 48 hours, the samples were visually inspected, tested for pH and particle-size distribution, and assayed by high-performance liquid chromatography for nizatidine concentration. No color change, precipitation, creaming, or oiling out was noted. For the 12 TNAs containing nizatidine, mean solution pH during the study was 5.88; stability of the lipid products requires pH values ≥5.5. Particle-size distribution did not differ appreciably between the nizatidine-containing and drug-free TNAs. Nizatidine concentrations remained greater than 90% of the initial concentration. Nizatidine at a theoretical concentration of 150 μg/mL was stable for 48 hours at 22 °C in TNA solutions containing 3% and 5% Intralipid or Liposyn II and did not appear to affect lipid emulsion stability.

Original languageEnglish
Pages (from-to)1507-1510
Number of pages4
JournalAmerican Journal of Hospital Pharmacy
Issue number7
StatePublished - 1991


  • Additives
  • Fat emulsions
  • Gastrointestinal drugs
  • Incompatibilities
  • Injections
  • Nizatidine
  • Nutrition
  • Safflower oil
  • Soybean oil
  • Stability
  • Storage

ASJC Scopus subject areas

  • Leadership and Management
  • Pharmaceutical Science


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