The purpose of this study was to determine the stability of reconstituted solutions of methohexital sodium over a 6-week period. Stability of methohexital was examined using reversed-phase high-performance liquid chromatography. The results indicate that reconstituted methohexital is extremely stable for up to 6 weeks when stored at 4°C. When stored at room temperature, reconstituted solutions of methohexital contained increasing levels of degradation products and showed a corresponding decrease in methohexital over a 6-week period. However, the rate of degradation of the drug was slow, with less than 10% of the methohexital undergoing breakdown. In addition, tests for microbial contamination of the solutions stored at room temperature and under refrigeration were negative for up to 6 weeks. This study demonstrates that methohexital, when stored under refrigeration for up to 6 weeks, is virtually chemically identical to a freshly reconstituted solution of the drug. When stored at room temperature, there is some degradation of the drug, but it is not known whether the small amount of degradation is clinically significant. This study emphasizes the importance of obtaining scientific data to support changes in guidelines related to handling and storage of drugs.
|Number of pages
|Journal of Oral and Maxillofacial Surgery
|Published - Apr 1994
Bibliographical noteFunding Information:
Received from the Department of Oral Health Practice, University of Kentucky College of Dentistry, Lexington, KY. * Assistant Professor. t Associate Professor. f Fourth-year Student Dentist. This study was supported by a Student Research Training Award from the Oral and Maxillofacial Surgery Foundation and by the University of Kentucky College of Dentistry. Address correspondence and reprint requests to Dr Beeman: D-442. University of Kentucky College of Dentistry, 800 Rose St. Lexington, KY 40536-0084.
ASJC Scopus subject areas
- Oral Surgery