TY - JOUR
T1 - Stability of SARS-CoV-2 and other airborne viruses under different stress conditions
AU - Fumagalli, Marcilio Jorge
AU - Capato, Carlos Fabiano
AU - de Castro-Jorge, Luiza Antunes
AU - de Souza, William Marciel
AU - Arruda, Eurico
AU - Figueiredo, Luiz Tadeu Moraes
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
PY - 2022/1
Y1 - 2022/1
N2 - Viral stability under stress conditions may directly affect viral dissemination, seasonality, and pathogenesis. We exposed airborne viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mumps virus, coxsackievirus B5, human rhinovirus A16, and respiratory syncytial virus, to different temperatures, UV light exposure time, pH values, and osmotic pressures and measured the remaining viral infectivity. Reduced thermal stability was observed for coxsackievirus B5 at 45 °C, while SARS-CoV-2 demonstrated residual infectivity at 55 °C. UV light exposure was an efficient means of viral inactivation but was less efficient for non-enveloped viruses. Rhinovirus A16 and respiratory syncytial virus demonstrated extreme sensitivity to acid conditions, while SARS-CoV-2, rhinovirus A16, and respiratory syncytial virus were unstable in an alkaline environment. The information obtained in this study will be useful for the development of viral inactivation methods and may be correlated with epidemiological and seasonal viral characteristics.
AB - Viral stability under stress conditions may directly affect viral dissemination, seasonality, and pathogenesis. We exposed airborne viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mumps virus, coxsackievirus B5, human rhinovirus A16, and respiratory syncytial virus, to different temperatures, UV light exposure time, pH values, and osmotic pressures and measured the remaining viral infectivity. Reduced thermal stability was observed for coxsackievirus B5 at 45 °C, while SARS-CoV-2 demonstrated residual infectivity at 55 °C. UV light exposure was an efficient means of viral inactivation but was less efficient for non-enveloped viruses. Rhinovirus A16 and respiratory syncytial virus demonstrated extreme sensitivity to acid conditions, while SARS-CoV-2, rhinovirus A16, and respiratory syncytial virus were unstable in an alkaline environment. The information obtained in this study will be useful for the development of viral inactivation methods and may be correlated with epidemiological and seasonal viral characteristics.
UR - http://www.scopus.com/inward/record.url?scp=85118426102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85118426102&partnerID=8YFLogxK
U2 - 10.1007/s00705-021-05293-7
DO - 10.1007/s00705-021-05293-7
M3 - Article
AN - SCOPUS:85118426102
SN - 0304-8608
VL - 167
SP - 183
EP - 187
JO - Archives of Virology
JF - Archives of Virology
IS - 1
ER -