Stability of the glutamate content of synaptosomes during their preparation

J. W. Geddes, J. D. Newstead, J. D. Wood

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The glutamate content of synaptosomal-enriched fractions is stable during the preparation and isolation of the organelles provided that the temperature of the preparation is maintained at 0-2°C and that inorganic ions are not added to the homogenizing and centrifugation media. Consequently, drug-induced in vivo changes in the glutamate content of nerve endings should be reflected by the corresponding changes in glutamate levels of synaptosomes prepared from the brain tissue.

Original languageEnglish
Pages (from-to)1107-1116
Number of pages10
JournalNeurochemical Research
Issue number10
StatePublished - Oct 1980

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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