Stabilizing gene regulatory networks through feedforward loops

C. Kadelka, D. Murrugarra, R. Laubenbacher

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The global dynamics of gene regulatory networks are known to show robustness to perturbations in the form of intrinsic and extrinsic noise, as well as mutations of individual genes. One molecular mechanism underlying this robustness has been identified as the action of so-called microRNAs that operate via feedforward loops. We present results of a computational study, using the modeling framework of stochastic Boolean networks, which explores the role that such network motifs play in stabilizing global dynamics. The paper introduces a new measure for the stability of stochastic networks. The results show that certain types of feedforward loops do indeed buffer the network against stochastic effects.

Original languageEnglish
Article number025107
Issue number2
StatePublished - Jun 2013

Bibliographical note

Funding Information:
This work was supported by the National Science Foundation under Grant No. CMMI-0908201.

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Mathematical Physics
  • General Physics and Astronomy
  • Applied Mathematics


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