The development of oxidant-free gold-catalyzed cross coupling reactions involving aryl halides have been hamstrung by the lack of gold catalysts capable of performing oxidative addition at Au(I) centers. Herein, we report the development of novel tricoordinate Au(I) catalysts supported by N,N-bidentate ligands and ligated by phosphine or arsine ligands for C-H functionalization without external oxidants to form biaryls with no homocoupling. The unsymmetrical character of the Au(I) catalyst is critical to facilitating this necessary orthogonal transformation. This study unveils yet another potential of Au(I) catalysis in biaryl synthesis.
|Number of pages||6|
|Journal||Journal of Catalysis|
|State||Published - Apr 2022|
Bibliographical noteFunding Information:
We are grateful to the University of Kentucky for funding. The authors acknowledge support of the Center for Pharmaceutical Research and Innovation (NIH P20 GM130456) and National Institutes of Health grant R01CA258421-01 (S.G.A.).
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Samuel G. Awuah reports financial support was provided by University of Kentucky. Samuel G. Awuah reports a relationship with University of Kentucky that includes: funding grants. Samuel G. Awuah has patent THREE-COORDINATE AU(I) PROBES AND USE IN SELECTIVELY DISRUPTING MITOCHONDRIA IN CANCER CELLS pending to University of Kentucky Research Foundation.
We would like to thank all the facilities at the University of Kentucky who provided support in completion of the experiments detailed in this manuscript. The UK NMR Center supported by NSF (CHE997738) and the UK X-ray facility supported by the MRI program from NSF (CHE-1625732).
© 2022 Elsevier Inc.
- C-H activation
- Gold catalysis
- Oxidative addition
- Tricoordinate gold
ASJC Scopus subject areas
- Physical and Theoretical Chemistry