Stable Au(I) catalysts for oxidant-free C-H functionalization with iodoarenes

R. Tyler Mertens, Charles E. Greif, James T. Coogle, Gilles Berger, Sean Parkin, Mark D. Watson, Samuel G. Awuah

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The development of oxidant-free gold-catalyzed cross coupling reactions involving aryl halides have been hamstrung by the lack of gold catalysts capable of performing oxidative addition at Au(I) centers. Herein, we report the development of novel tricoordinate Au(I) catalysts supported by N,N-bidentate ligands and ligated by phosphine or arsine ligands for C-H functionalization without external oxidants to form biaryls with no homocoupling. The unsymmetrical character of the Au(I) catalyst is critical to facilitating this necessary orthogonal transformation. This study unveils yet another potential of Au(I) catalysis in biaryl synthesis.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalJournal of Catalysis
Volume408
DOIs
StatePublished - Apr 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc.

Keywords

  • C-H activation
  • Gold catalysis
  • Oxidative addition
  • Tricoordinate gold

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry

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