Stable isotope-assisted metabolomics in cancer research

Andrew N. Lane; Teresa W.M. Fan; Richard M. Higashi

doi:10.1002/iub.17

Stable isotope-assisted metabolomics in cancer research

Andrew N. Lane, Teresa W.M. Fan, Richard M. Higashi

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Stable Isotopes are nontoxic, naturally occurring elemental surrogates that are fully compatible with live organisms, including humans in a clinical setting. The ability to enrich common compounds with rare isotopes such as carbon (¹³C) and nitrogen (¹⁵N) is the only practical means by which metabolic pathways can be traced, performed by following the fate of individual atoms from the source molecules to products via metabolic transformation. Changes in regulation of pathways are therefore captured by this approach, which leads to deeper understanding of fundamental biochemistry of cancer compared with non-cancerous cells, which can lead to new diagnostic tools.

Original language	English
Pages (from-to)	124-129
Number of pages	6
Journal	IUBMB Life
Volume	60
Issue number	2
DOIs	https://doi.org/10.1002/iub.17
State	Published - 2008

Keywords

Isotopomer pathway analysis
Mass spectrometry
NMR
Stable Isotopes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics
Clinical Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/iub.17

Cite this

@article{9f050945842647c8b5ca1902411508d3,

title = "Stable isotope-assisted metabolomics in cancer research",

abstract = "Stable Isotopes are nontoxic, naturally occurring elemental surrogates that are fully compatible with live organisms, including humans in a clinical setting. The ability to enrich common compounds with rare isotopes such as carbon (13C) and nitrogen (15N) is the only practical means by which metabolic pathways can be traced, performed by following the fate of individual atoms from the source molecules to products via metabolic transformation. Changes in regulation of pathways are therefore captured by this approach, which leads to deeper understanding of fundamental biochemistry of cancer compared with non-cancerous cells, which can lead to new diagnostic tools.",

keywords = "Isotopomer pathway analysis, Mass spectrometry, NMR, Stable Isotopes",

author = "Lane, {Andrew N.} and Fan, {Teresa W.M.} and Higashi, {Richard M.}",

year = "2008",

doi = "10.1002/iub.17",

language = "English",

volume = "60",

pages = "124--129",

number = "2",

}

TY - JOUR

T1 - Stable isotope-assisted metabolomics in cancer research

AU - Lane, Andrew N.

AU - Fan, Teresa W.M.

AU - Higashi, Richard M.

PY - 2008

Y1 - 2008

N2 - Stable Isotopes are nontoxic, naturally occurring elemental surrogates that are fully compatible with live organisms, including humans in a clinical setting. The ability to enrich common compounds with rare isotopes such as carbon (13C) and nitrogen (15N) is the only practical means by which metabolic pathways can be traced, performed by following the fate of individual atoms from the source molecules to products via metabolic transformation. Changes in regulation of pathways are therefore captured by this approach, which leads to deeper understanding of fundamental biochemistry of cancer compared with non-cancerous cells, which can lead to new diagnostic tools.

AB - Stable Isotopes are nontoxic, naturally occurring elemental surrogates that are fully compatible with live organisms, including humans in a clinical setting. The ability to enrich common compounds with rare isotopes such as carbon (13C) and nitrogen (15N) is the only practical means by which metabolic pathways can be traced, performed by following the fate of individual atoms from the source molecules to products via metabolic transformation. Changes in regulation of pathways are therefore captured by this approach, which leads to deeper understanding of fundamental biochemistry of cancer compared with non-cancerous cells, which can lead to new diagnostic tools.

KW - Isotopomer pathway analysis

KW - Mass spectrometry

KW - NMR

KW - Stable Isotopes

UR - http://www.scopus.com/inward/record.url?scp=42149164983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42149164983&partnerID=8YFLogxK

U2 - 10.1002/iub.17

DO - 10.1002/iub.17

M3 - Review article

C2 - 18380001

AN - SCOPUS:42149164983

SN - 1521-6543

VL - 60

SP - 124

EP - 129

JO - IUBMB Life

JF - IUBMB Life

IS - 2

ER -

Stable isotope-assisted metabolomics in cancer research

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this