Staggering the administration of polymyxin B and meropenem in time-kill against carbapenem-resistant Enterobacteriaceae exhibiting a wide range of meropenem MICs

Brandon Kulengowski, Justin A. Clark, David S. Burgess

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Little is known regarding the appropriate timing and sequencing of a carbapenem and polymyxin in combination against carbapenem-resistant Enterobacteriaceae. Meropenem and polymyxin B were administered simultaneously or 1 agent 2 h prior to the other, in vitro. The carbapenem should be administered prior to the polymyxin when used in combination.

Original languageEnglish
Pages (from-to)261-264
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume93
Issue number3
DOIs
StatePublished - Mar 2019

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

  • Carbapenem-resistant Enterobacteriaceae
  • Meropenem
  • Polymyxin B
  • Staggered administration
  • Time-kill

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Staggering the administration of polymyxin B and meropenem in time-kill against carbapenem-resistant Enterobacteriaceae exhibiting a wide range of meropenem MICs'. Together they form a unique fingerprint.

Cite this