TY - JOUR
T1 - Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation
AU - Murach, Kevin A.
AU - Fry, Christopher S.
AU - Kirby, Tyler J.
AU - Jackson, Janna R.
AU - Lee, Jonah D.
AU - White, Sarah H.
AU - Dupont-Versteegden, Esther E.
AU - McCarthy, John J.
AU - Peterson, Charlotte A.
N1 - Publisher Copyright:
© 2018 Int. Union Physiol. Sci./Am. Physiol. Soc.
PY - 2018/1
Y1 - 2018/1
N2 - Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy.
AB - Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy.
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U2 - 10.1152/physiol.00019.2017
DO - 10.1152/physiol.00019.2017
M3 - Review article
C2 - 29212890
AN - SCOPUS:85037625785
SN - 1548-9213
VL - 33
SP - 26
EP - 38
JO - Physiology
JF - Physiology
IS - 1
ER -