Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy.
|Number of pages||13|
|State||Published - Jan 2018|
Bibliographical noteFunding Information:
This work was supported by National Institutes of Health (NIH) Ruth L. Kirchstein Postdoctoral Fellowships to K.A.M. (AR-071753) and C.S.F. (AR-065337), NIH grants to C.A.P. (AG-034453) and C.A.P./J.J.M. (AR-060701, AG-049806), an NIH National Center for Advancing Translational Sciences grant (UL1 TR-000117), and an Ellison Medical Foundation/American Federation for Aging Research Fellowship to J.D.L. (EPD 12102).
© 2018 Int. Union Physiol. Sci./Am. Physiol. Soc.
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