Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation

Kevin A. Murach; Christopher S. Fry; Tyler J. Kirby; Janna R. Jackson; Jonah D. Lee; Sarah H. White; Esther E. Dupont-Versteegden; John J. McCarthy; Charlotte A. Peterson

doi:10.1152/physiol.00019.2017

Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation

Kevin A. Murach, Christopher S. Fry, Tyler J. Kirby, Janna R. Jackson, Jonah D. Lee, Sarah H. White, Esther E. Dupont-Versteegden, John J. McCarthy, Charlotte A. Peterson

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy.

Original language	English
Pages (from-to)	26-38
Number of pages	13
Journal	Physiology
Volume	33
Issue number	1
DOIs	https://doi.org/10.1152/physiol.00019.2017
State	Published - Jan 2018

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health (NIH) Ruth L. Kirchstein Postdoctoral Fellowships to K.A.M. (AR-071753) and C.S.F. (AR-065337), NIH grants to C.A.P. (AG-034453) and C.A.P./J.J.M. (AR-060701, AG-049806), an NIH National Center for Advancing Translational Sciences grant (UL1 TR-000117), and an Ellison Medical Foundation/American Federation for Aging Research Fellowship to J.D.L. (EPD 12102).

Publisher Copyright:
© 2018 Int. Union Physiol. Sci./Am. Physiol. Soc.

ASJC Scopus subject areas

Physiology

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10.1152/physiol.00019.2017

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title = "Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation",

abstract = "Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy.",

author = "Murach, {Kevin A.} and Fry, {Christopher S.} and Kirby, {Tyler J.} and Jackson, {Janna R.} and Lee, {Jonah D.} and White, {Sarah H.} and Dupont-Versteegden, {Esther E.} and McCarthy, {John J.} and Peterson, {Charlotte A.}",

note = "Funding Information: This work was supported by National Institutes of Health (NIH) Ruth L. Kirchstein Postdoctoral Fellowships to K.A.M. (AR-071753) and C.S.F. (AR-065337), NIH grants to C.A.P. (AG-034453) and C.A.P./J.J.M. (AR-060701, AG-049806), an NIH National Center for Advancing Translational Sciences grant (UL1 TR-000117), and an Ellison Medical Foundation/American Federation for Aging Research Fellowship to J.D.L. (EPD 12102). Publisher Copyright: {\textcopyright} 2018 Int. Union Physiol. Sci./Am. Physiol. Soc.",

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doi = "10.1152/physiol.00019.2017",

language = "English",

volume = "33",

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AU - Murach, Kevin A.

AU - Fry, Christopher S.

AU - Kirby, Tyler J.

AU - Jackson, Janna R.

AU - Lee, Jonah D.

AU - White, Sarah H.

AU - Dupont-Versteegden, Esther E.

AU - McCarthy, John J.

AU - Peterson, Charlotte A.

N1 - Funding Information: This work was supported by National Institutes of Health (NIH) Ruth L. Kirchstein Postdoctoral Fellowships to K.A.M. (AR-071753) and C.S.F. (AR-065337), NIH grants to C.A.P. (AG-034453) and C.A.P./J.J.M. (AR-060701, AG-049806), an NIH National Center for Advancing Translational Sciences grant (UL1 TR-000117), and an Ellison Medical Foundation/American Federation for Aging Research Fellowship to J.D.L. (EPD 12102). Publisher Copyright: © 2018 Int. Union Physiol. Sci./Am. Physiol. Soc.

PY - 2018/1

Y1 - 2018/1

N2 - Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy.

AB - Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy.

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Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation

Abstract

Bibliographical note

ASJC Scopus subject areas

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