Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation

Kevin A. Murach, Christopher S. Fry, Tyler J. Kirby, Janna R. Jackson, Jonah D. Lee, Sarah H. White, Esther E. Dupont-Versteegden, John J. McCarthy, Charlotte A. Peterson

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations


Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy.

Original languageEnglish
Pages (from-to)26-38
Number of pages13
Issue number1
StatePublished - Jan 2018

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health (NIH) Ruth L. Kirchstein Postdoctoral Fellowships to K.A.M. (AR-071753) and C.S.F. (AR-065337), NIH grants to C.A.P. (AG-034453) and C.A.P./J.J.M. (AR-060701, AG-049806), an NIH National Center for Advancing Translational Sciences grant (UL1 TR-000117), and an Ellison Medical Foundation/American Federation for Aging Research Fellowship to J.D.L. (EPD 12102).

Publisher Copyright:
© 2018 Int. Union Physiol. Sci./Am. Physiol. Soc.

ASJC Scopus subject areas

  • Physiology


Dive into the research topics of 'Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation'. Together they form a unique fingerprint.

Cite this