Statistical inference for tumor growth inhibition T/C ratio

Jianrong Wu

doi:10.1080/10543401003618983

Statistical inference for tumor growth inhibition T/C ratio

Jianrong Wu

Internal Medicine

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The tumor growth inhibition T/C ratio is commonly used to quantify treatment effects in drug screening tumor xenograft experiments. The T/C ratio is converted to an antitumor activity rating using an arbitrary cutoff point and often without any formal statistical inference. Here, we applied a nonparametric bootstrap method and a small sample likelihood ratio statistic to make a statistical inference of the T/C ratio, including both hypothesis testing and a confidence interval estimate. Furthermore, sample size and power are also discussed for statistical design of tumor xenograft experiments. Tumor xenograft data from an actual experiment were analyzed to illustrate the application.

Original language	English
Pages (from-to)	954-964
Number of pages	11
Journal	Journal of Biopharmaceutical Statistics
Volume	20
Issue number	5
DOIs	https://doi.org/10.1080/10543401003618983
State	Published - Sep 2010

Bibliographical note

Funding Information:
The author is thankful to the associate editor and anonymous referees whose careful reading and constructive comments improved this article. This work was supported in part by National Cancer Institute (NCI) support grant CA21765, NO1-CM-42216, and the American Lebanese Syrian Associated Charities (ALSAC).

Keywords

Bootstrap
Confidence interval
Hypothesis
Likelihood ratio
Log-normal
Sample size
Tumor growth inhibition
Xenografts

ASJC Scopus subject areas

Statistics and Probability
Pharmacology
Pharmacology (medical)

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10.1080/10543401003618983

Cite this

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title = "Statistical inference for tumor growth inhibition T/C ratio",

abstract = "The tumor growth inhibition T/C ratio is commonly used to quantify treatment effects in drug screening tumor xenograft experiments. The T/C ratio is converted to an antitumor activity rating using an arbitrary cutoff point and often without any formal statistical inference. Here, we applied a nonparametric bootstrap method and a small sample likelihood ratio statistic to make a statistical inference of the T/C ratio, including both hypothesis testing and a confidence interval estimate. Furthermore, sample size and power are also discussed for statistical design of tumor xenograft experiments. Tumor xenograft data from an actual experiment were analyzed to illustrate the application.",

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N2 - The tumor growth inhibition T/C ratio is commonly used to quantify treatment effects in drug screening tumor xenograft experiments. The T/C ratio is converted to an antitumor activity rating using an arbitrary cutoff point and often without any formal statistical inference. Here, we applied a nonparametric bootstrap method and a small sample likelihood ratio statistic to make a statistical inference of the T/C ratio, including both hypothesis testing and a confidence interval estimate. Furthermore, sample size and power are also discussed for statistical design of tumor xenograft experiments. Tumor xenograft data from an actual experiment were analyzed to illustrate the application.

AB - The tumor growth inhibition T/C ratio is commonly used to quantify treatment effects in drug screening tumor xenograft experiments. The T/C ratio is converted to an antitumor activity rating using an arbitrary cutoff point and often without any formal statistical inference. Here, we applied a nonparametric bootstrap method and a small sample likelihood ratio statistic to make a statistical inference of the T/C ratio, including both hypothesis testing and a confidence interval estimate. Furthermore, sample size and power are also discussed for statistical design of tumor xenograft experiments. Tumor xenograft data from an actual experiment were analyzed to illustrate the application.

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KW - Confidence interval

KW - Hypothesis

KW - Likelihood ratio

KW - Log-normal

KW - Sample size

KW - Tumor growth inhibition

KW - Xenografts

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Statistical inference for tumor growth inhibition T/C ratio

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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