Stereotactic radiosurgery associated neurotoxicity

William H. St. Clair, Curtis A. Given

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Stereotactic radiosurgery (SRS) is an evolving therapeutic modality for well demarcated intracranial lesions. Since the inception of stereotactic radiosurgery the types of parenchymal CNS lesions addressed by this mode of treatment has increased. All modern stereotactic radiosurgical procedures employ several common features. Patients are fitted with a stereotactic head frame or fiducial markers followed by radiographic imaging which allows for external reference points and three-dimensional mapping of the intracranial lesion. Armed with this information a highly conformal treatment plan is developed to deliver a high dose of radiation to a sharply defined target, with rapid dose fall-off outside the lesion volume. While an extremely effective therapeutic option, SRS is not without risk of neurotoxicity, with radiation necrosis being the most commonly recognized complication. The neurotoxic effects of SRS are reviewed and discussed.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalTechnology in Cancer Research and Treatment
Issue number2
StatePublished - Apr 2003

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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