TY - JOUR
T1 - Stereotactic radiosurgery associated neurotoxicity
AU - St. Clair, William H.
AU - Given, Curtis A.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2003/4
Y1 - 2003/4
N2 - Stereotactic radiosurgery (SRS) is an evolving therapeutic modality for well demarcated intracranial lesions. Since the inception of stereotactic radiosurgery the types of parenchymal CNS lesions addressed by this mode of treatment has increased. All modern stereotactic radiosurgical procedures employ several common features. Patients are fitted with a stereotactic head frame or fiducial markers followed by radiographic imaging which allows for external reference points and three-dimensional mapping of the intracranial lesion. Armed with this information a highly conformal treatment plan is developed to deliver a high dose of radiation to a sharply defined target, with rapid dose fall-off outside the lesion volume. While an extremely effective therapeutic option, SRS is not without risk of neurotoxicity, with radiation necrosis being the most commonly recognized complication. The neurotoxic effects of SRS are reviewed and discussed.
AB - Stereotactic radiosurgery (SRS) is an evolving therapeutic modality for well demarcated intracranial lesions. Since the inception of stereotactic radiosurgery the types of parenchymal CNS lesions addressed by this mode of treatment has increased. All modern stereotactic radiosurgical procedures employ several common features. Patients are fitted with a stereotactic head frame or fiducial markers followed by radiographic imaging which allows for external reference points and three-dimensional mapping of the intracranial lesion. Armed with this information a highly conformal treatment plan is developed to deliver a high dose of radiation to a sharply defined target, with rapid dose fall-off outside the lesion volume. While an extremely effective therapeutic option, SRS is not without risk of neurotoxicity, with radiation necrosis being the most commonly recognized complication. The neurotoxic effects of SRS are reviewed and discussed.
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U2 - 10.1177/153303460300200211
DO - 10.1177/153303460300200211
M3 - Review article
C2 - 12680796
AN - SCOPUS:0038668879
SN - 1533-0346
VL - 2
SP - 147
EP - 151
JO - Technology in Cancer Research and Treatment
JF - Technology in Cancer Research and Treatment
IS - 2
ER -