Steroid-loaded hemostatic nanoparticles combat lung injury after blast trauma

W. Brad Hubbard, Margaret M. Lashof-Sullivan, Erin B. Lavik, Pamela J. Vandevord

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


In response to the lack of therapeutics for internal bleeding following a traumatic event, we synthesized hemostatic dexamethasone nanoparticles (hDNP) to help alleviate internal hemorrhaging. hDNP consist of a block copolymer, poly(lactic-co-glycolic acid)-poly(l-lysine)-poly(ethylene glycol) conjugated to a peptide, glycine-arginine-glycine-aspartic acid-serine (GRGDS). These particles were evaluated as treatment for primary blast lung injury in a rodent model. Animals were randomly placed into test and control groups, exposed to blast and given immediate injection. Recovery was assessed using physiological parameters and immunohistochemistry. We found that dexamethasone-loaded hemostatic nanoparticles alleviate physiological deprivation caused by blast injury and reduce lung injury damage.

Original languageEnglish
Pages (from-to)387-391
Number of pages5
JournalACS Macro Letters
Issue number4
StatePublished - Apr 21 2015

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry


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