Steroid-loaded hemostatic nanoparticles combat lung injury after blast trauma

W. Brad Hubbard; Margaret M. Lashof-Sullivan; Erin B. Lavik; Pamela J. Vandevord

doi:10.1021/acsmacrolett.5b00061

Steroid-loaded hemostatic nanoparticles combat lung injury after blast trauma

W. Brad Hubbard
, Margaret M. Lashof-Sullivan
, Erin B. Lavik
, Pamela J. Vandevord

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

In response to the lack of therapeutics for internal bleeding following a traumatic event, we synthesized hemostatic dexamethasone nanoparticles (hDNP) to help alleviate internal hemorrhaging. hDNP consist of a block copolymer, poly(lactic-co-glycolic acid)-poly(l-lysine)-poly(ethylene glycol) conjugated to a peptide, glycine-arginine-glycine-aspartic acid-serine (GRGDS). These particles were evaluated as treatment for primary blast lung injury in a rodent model. Animals were randomly placed into test and control groups, exposed to blast and given immediate injection. Recovery was assessed using physiological parameters and immunohistochemistry. We found that dexamethasone-loaded hemostatic nanoparticles alleviate physiological deprivation caused by blast injury and reduce lung injury damage.

Original language	English
Pages (from-to)	387-391
Number of pages	5
Journal	ACS Macro Letters
Volume	4
Issue number	4
DOIs	https://doi.org/10.1021/acsmacrolett.5b00061
State	Published - Apr 21 2015

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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10.1021/acsmacrolett.5b00061

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title = "Steroid-loaded hemostatic nanoparticles combat lung injury after blast trauma",

abstract = "In response to the lack of therapeutics for internal bleeding following a traumatic event, we synthesized hemostatic dexamethasone nanoparticles (hDNP) to help alleviate internal hemorrhaging. hDNP consist of a block copolymer, poly(lactic-co-glycolic acid)-poly(l-lysine)-poly(ethylene glycol) conjugated to a peptide, glycine-arginine-glycine-aspartic acid-serine (GRGDS). These particles were evaluated as treatment for primary blast lung injury in a rodent model. Animals were randomly placed into test and control groups, exposed to blast and given immediate injection. Recovery was assessed using physiological parameters and immunohistochemistry. We found that dexamethasone-loaded hemostatic nanoparticles alleviate physiological deprivation caused by blast injury and reduce lung injury damage.",

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doi = "10.1021/acsmacrolett.5b00061",

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AU - Hubbard, W. Brad

AU - Lashof-Sullivan, Margaret M.

AU - Lavik, Erin B.

AU - Vandevord, Pamela J.

PY - 2015/4/21

Y1 - 2015/4/21

N2 - In response to the lack of therapeutics for internal bleeding following a traumatic event, we synthesized hemostatic dexamethasone nanoparticles (hDNP) to help alleviate internal hemorrhaging. hDNP consist of a block copolymer, poly(lactic-co-glycolic acid)-poly(l-lysine)-poly(ethylene glycol) conjugated to a peptide, glycine-arginine-glycine-aspartic acid-serine (GRGDS). These particles were evaluated as treatment for primary blast lung injury in a rodent model. Animals were randomly placed into test and control groups, exposed to blast and given immediate injection. Recovery was assessed using physiological parameters and immunohistochemistry. We found that dexamethasone-loaded hemostatic nanoparticles alleviate physiological deprivation caused by blast injury and reduce lung injury damage.

AB - In response to the lack of therapeutics for internal bleeding following a traumatic event, we synthesized hemostatic dexamethasone nanoparticles (hDNP) to help alleviate internal hemorrhaging. hDNP consist of a block copolymer, poly(lactic-co-glycolic acid)-poly(l-lysine)-poly(ethylene glycol) conjugated to a peptide, glycine-arginine-glycine-aspartic acid-serine (GRGDS). These particles were evaluated as treatment for primary blast lung injury in a rodent model. Animals were randomly placed into test and control groups, exposed to blast and given immediate injection. Recovery was assessed using physiological parameters and immunohistochemistry. We found that dexamethasone-loaded hemostatic nanoparticles alleviate physiological deprivation caused by blast injury and reduce lung injury damage.

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JO - ACS Macro Letters

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Steroid-loaded hemostatic nanoparticles combat lung injury after blast trauma

Abstract

Bibliographical note

ASJC Scopus subject areas

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