Stochastic modeling and prediction of experimental seizures in Sprague-Dawley rats

Sridhar Sunderam, Ivan Osorio, Mark G. Frei, James F. Watkins

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Most seizure prediction methods are based on nonlinear dynamic techniques, which are highly computationally expensive, thus limiting their clinical usefulness. The authors propose a different approach for prediction that uses a stochastic Markov chain model. Seizure (Ts) and interictal (Ti) durations were measured from 11 rats treated with 3-mercaptopropionic acid. The duration of a seizure Ts was used to predict the time (Ti2) to the next one. Ts and Ti were distributed bimodally into short (S) and long (L), generating four probable transitions: S → S, S → L, L → S, and L → L. The joint probability density f (T2, Ti2) was modeled, and was used to predict Ti2 given Ts. An identical model predicted Ts given the duration Ti1 of the preceding interictal interval. The median prediction error was 3.0 ± 3.5 seconds for Ts (given Ti1) and 6.5 ± 2.0 seconds for Ti2 (given Ts). In comparison, ranges for observed values were 2.3 seconds < T2 < 120 seconds and 6.6 seconds < Ti < 782 seconds. These results suggest that stochastic models are potentially useful tools for the prediction of seizures. Further investigation of the probable temporal interdependence between the ictal and interictal states may provide valuable insight into the dynamics of the epileptic brain.

Original languageEnglish
Pages (from-to)275-282
Number of pages8
JournalJournal of Clinical Neurophysiology
Issue number3
StatePublished - 2001


  • 3-MPA
  • Experimental epilepsy models
  • Rat
  • Seizure prediction
  • Stochastic

ASJC Scopus subject areas

  • Physiology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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