Strained ruthenium complexes are potent light-activated anticancer agents

Brock S. Howerton; David K. Heidary; Edith C. Glazer

doi:10.1021/ja3009677

Strained ruthenium complexes are potent light-activated anticancer agents

Brock S. Howerton, David K. Heidary, Edith C. Glazer

Chemistry

Research output: Contribution to journal › Article › peer-review

427 Scopus citations

Abstract

Strained ruthenium (Ru) complexes have been synthesized and characterized as novel agents for photodynamic therapy (PDT). The complexes are inert until triggered by visible light, which induces ligand loss and covalent modification of DNA. An increase in cytotoxicity of 2 orders of magnitude is observed with light activation in cancer cells, and the compounds display potencies superior to cisplatin against 3D tumor spheroids. The use of intramolecular strain may be applied as a general paradigm to develop light-activated ruthenium complexes for PDT applications.

Original language	English
Pages (from-to)	8324-8327
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	134
Issue number	20
DOIs	https://doi.org/10.1021/ja3009677
State	Published - May 23 2012

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/ja3009677

Cite this

@article{74fb8ae300d04767b72e35b8be53d64d,

title = "Strained ruthenium complexes are potent light-activated anticancer agents",

abstract = "Strained ruthenium (Ru) complexes have been synthesized and characterized as novel agents for photodynamic therapy (PDT). The complexes are inert until triggered by visible light, which induces ligand loss and covalent modification of DNA. An increase in cytotoxicity of 2 orders of magnitude is observed with light activation in cancer cells, and the compounds display potencies superior to cisplatin against 3D tumor spheroids. The use of intramolecular strain may be applied as a general paradigm to develop light-activated ruthenium complexes for PDT applications.",

author = "Howerton, {Brock S.} and Heidary, {David K.} and Glazer, {Edith C.}",

year = "2012",

month = may,

day = "23",

doi = "10.1021/ja3009677",

language = "English",

volume = "134",

pages = "8324--8327",

number = "20",

}

TY - JOUR

T1 - Strained ruthenium complexes are potent light-activated anticancer agents

AU - Howerton, Brock S.

AU - Heidary, David K.

AU - Glazer, Edith C.

PY - 2012/5/23

Y1 - 2012/5/23

N2 - Strained ruthenium (Ru) complexes have been synthesized and characterized as novel agents for photodynamic therapy (PDT). The complexes are inert until triggered by visible light, which induces ligand loss and covalent modification of DNA. An increase in cytotoxicity of 2 orders of magnitude is observed with light activation in cancer cells, and the compounds display potencies superior to cisplatin against 3D tumor spheroids. The use of intramolecular strain may be applied as a general paradigm to develop light-activated ruthenium complexes for PDT applications.

AB - Strained ruthenium (Ru) complexes have been synthesized and characterized as novel agents for photodynamic therapy (PDT). The complexes are inert until triggered by visible light, which induces ligand loss and covalent modification of DNA. An increase in cytotoxicity of 2 orders of magnitude is observed with light activation in cancer cells, and the compounds display potencies superior to cisplatin against 3D tumor spheroids. The use of intramolecular strain may be applied as a general paradigm to develop light-activated ruthenium complexes for PDT applications.

UR - http://www.scopus.com/inward/record.url?scp=84861395922&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861395922&partnerID=8YFLogxK

U2 - 10.1021/ja3009677

DO - 10.1021/ja3009677

M3 - Article

C2 - 22553960

AN - SCOPUS:84861395922

SN - 0002-7863

VL - 134

SP - 8324

EP - 8327

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 20

ER -

Strained ruthenium complexes are potent light-activated anticancer agents

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this