Stress, coping, and circadian disruption among women awaiting breast cancer surgery

Eric Dedert; Elizabeth Lush; Anees Chagpar; Firdaus S. Dhabhar; Suzanne C. Segerstrom; David Spiegel; Ehab Dayyat; Meagan Daup; Kelly McMasters; Sandra E. Sephton

doi:10.1007/s12160-012-9352-y

Stress, coping, and circadian disruption among women awaiting breast cancer surgery

Eric Dedert, Elizabeth Lush, Anees Chagpar, Firdaus S. Dhabhar, Suzanne C. Segerstrom, David Spiegel, Ehab Dayyat, Meagan Daup, Kelly McMasters, Sandra E. Sephton

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Background Psychological distress and coping related to a breast cancer diagnosis can profoundly affect psychological adjustment, possibly resulting in the disruption of circadian rest/ activity and cortisol rhythms, which are prognostic for early mortality inmetastatic colorectal and breast cancers, respectively. Purpose This study aims to explore the relationships of cancer-specific distress and avoidant coping with rest/activity and cortisol rhythmdisruption in the period between diagnosis and breast cancer surgery. Methods Fifty-seven presurgical breast cancer patients provided daily self-reports of cancer-specific distress and avoidant coping as well as actigraphic and salivary cortisol data. Results Distress and avoidant coping were related to rest/ activity rhythm disruption (daytime sedentariness, inconsistent rhythms). Patients with disrupted rest/activity cycles had flattened diurnal cortisol rhythms. Conclusions Maladaptive psychological responses to breast cancer diagnosis were associated with disruption of circadian rest/activity rhythms. Given that circadian cycles regulate tumor growth, we need greater understanding of possible psychosocial effects in cancer-related circadian disruption.

Original language	English
Pages (from-to)	10-20
Number of pages	11
Journal	Annals of Behavioral Medicine
Volume	44
Issue number	1
DOIs	https://doi.org/10.1007/s12160-012-9352-y
State	Published - Aug 2012

Bibliographical note

Funding Information:
Acknowledgments We would like to thank the women who participated in this research despite numerous other time demands. We also thank all of the nursing staff and research assistants who worked on recruitment and data collection and management. This study was funded by the University of Louisville Internal Research Incentive Grant for Research on Women.

Funding

Acknowledgments We would like to thank the women who participated in this research despite numerous other time demands. We also thank all of the nursing staff and research assistants who worked on recruitment and data collection and management. This study was funded by the University of Louisville Internal Research Incentive Grant for Research on Women.

Funders	Funder number
University of Kentucky, University of Louisville

Keywords

Actigraphy
Breast cancer
Circadian rhythm
Cortisol
Rest/activity
Sleep

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12160-012-9352-y

Cite this

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title = "Stress, coping, and circadian disruption among women awaiting breast cancer surgery",

abstract = "Background Psychological distress and coping related to a breast cancer diagnosis can profoundly affect psychological adjustment, possibly resulting in the disruption of circadian rest/ activity and cortisol rhythms, which are prognostic for early mortality inmetastatic colorectal and breast cancers, respectively. Purpose This study aims to explore the relationships of cancer-specific distress and avoidant coping with rest/activity and cortisol rhythmdisruption in the period between diagnosis and breast cancer surgery. Methods Fifty-seven presurgical breast cancer patients provided daily self-reports of cancer-specific distress and avoidant coping as well as actigraphic and salivary cortisol data. Results Distress and avoidant coping were related to rest/ activity rhythm disruption (daytime sedentariness, inconsistent rhythms). Patients with disrupted rest/activity cycles had flattened diurnal cortisol rhythms. Conclusions Maladaptive psychological responses to breast cancer diagnosis were associated with disruption of circadian rest/activity rhythms. Given that circadian cycles regulate tumor growth, we need greater understanding of possible psychosocial effects in cancer-related circadian disruption.",

keywords = "Actigraphy, Breast cancer, Circadian rhythm, Cortisol, Rest/activity, Sleep",

author = "Eric Dedert and Elizabeth Lush and Anees Chagpar and Dhabhar, {Firdaus S.} and Segerstrom, {Suzanne C.} and David Spiegel and Ehab Dayyat and Meagan Daup and Kelly McMasters and Sephton, {Sandra E.}",

note = "Funding Information: Acknowledgments We would like to thank the women who participated in this research despite numerous other time demands. We also thank all of the nursing staff and research assistants who worked on recruitment and data collection and management. This study was funded by the University of Louisville Internal Research Incentive Grant for Research on Women.",

year = "2012",

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doi = "10.1007/s12160-012-9352-y",

language = "English",

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AU - Dedert, Eric

AU - Lush, Elizabeth

AU - Chagpar, Anees

AU - Dhabhar, Firdaus S.

AU - Segerstrom, Suzanne C.

AU - Spiegel, David

AU - Dayyat, Ehab

AU - Daup, Meagan

AU - McMasters, Kelly

AU - Sephton, Sandra E.

N1 - Funding Information: Acknowledgments We would like to thank the women who participated in this research despite numerous other time demands. We also thank all of the nursing staff and research assistants who worked on recruitment and data collection and management. This study was funded by the University of Louisville Internal Research Incentive Grant for Research on Women.

PY - 2012/8

Y1 - 2012/8

N2 - Background Psychological distress and coping related to a breast cancer diagnosis can profoundly affect psychological adjustment, possibly resulting in the disruption of circadian rest/ activity and cortisol rhythms, which are prognostic for early mortality inmetastatic colorectal and breast cancers, respectively. Purpose This study aims to explore the relationships of cancer-specific distress and avoidant coping with rest/activity and cortisol rhythmdisruption in the period between diagnosis and breast cancer surgery. Methods Fifty-seven presurgical breast cancer patients provided daily self-reports of cancer-specific distress and avoidant coping as well as actigraphic and salivary cortisol data. Results Distress and avoidant coping were related to rest/ activity rhythm disruption (daytime sedentariness, inconsistent rhythms). Patients with disrupted rest/activity cycles had flattened diurnal cortisol rhythms. Conclusions Maladaptive psychological responses to breast cancer diagnosis were associated with disruption of circadian rest/activity rhythms. Given that circadian cycles regulate tumor growth, we need greater understanding of possible psychosocial effects in cancer-related circadian disruption.

AB - Background Psychological distress and coping related to a breast cancer diagnosis can profoundly affect psychological adjustment, possibly resulting in the disruption of circadian rest/ activity and cortisol rhythms, which are prognostic for early mortality inmetastatic colorectal and breast cancers, respectively. Purpose This study aims to explore the relationships of cancer-specific distress and avoidant coping with rest/activity and cortisol rhythmdisruption in the period between diagnosis and breast cancer surgery. Methods Fifty-seven presurgical breast cancer patients provided daily self-reports of cancer-specific distress and avoidant coping as well as actigraphic and salivary cortisol data. Results Distress and avoidant coping were related to rest/ activity rhythm disruption (daytime sedentariness, inconsistent rhythms). Patients with disrupted rest/activity cycles had flattened diurnal cortisol rhythms. Conclusions Maladaptive psychological responses to breast cancer diagnosis were associated with disruption of circadian rest/activity rhythms. Given that circadian cycles regulate tumor growth, we need greater understanding of possible psychosocial effects in cancer-related circadian disruption.

KW - Actigraphy

KW - Breast cancer

KW - Circadian rhythm

KW - Cortisol

KW - Rest/activity

KW - Sleep

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Stress, coping, and circadian disruption among women awaiting breast cancer surgery

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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