Cholinergic neuropil and cell bodies were identified in the human striatum by immunohistochemistry carried out with a polyclonal antibody raised against choline acetyltransferase (ChAT). The cholinergic neuropil was not uniformly distributed in the striatum, and especially in the caudate nucleus ChAT-poor zones corresponding to acetylcholinesterase (AChE)-poor striosomes were identified. Striosomal organization of ChAT-positive neuropil was also detected in striatal tissue from patients who had suffered parkinsonian and choreic disorders.
|Number of pages||6|
|State||Published - Jan 16 1989|
Bibliographical noteFunding Information:
We thank Drs. J.J. Hauw, F. Javoy-Agid and P. Cervera for their help in the tissue preparation, Drs. G. Corkidi and J.C. Bisconte for their help in image analysis and H.F. Hall who is responsible for the photography. This work was supported by the Tourette Syndrome Association, NINCDS grant IR01 NS25529, Foundation Simone and Cino del Duca, United Parkinson's Disease Foundation, the Seaver Institute, NIH grant AG 05893 and INSERM. E.C. Hirsch is a fellow of the Fondation pour la Recherche Medicale.
- Choline acetyltransferase
ASJC Scopus subject areas
- Neuroscience (all)