Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum

Etienne C. Hirsch; Ann M. Graybiel; Louis B. Hersh; Charles Duyckaerts; Yves Agid

doi:10.1016/0304-3940(89)90048-7

Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum

Etienne C. Hirsch, Ann M. Graybiel, Louis B. Hersh, Charles Duyckaerts, Yves Agid

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Cholinergic neuropil and cell bodies were identified in the human striatum by immunohistochemistry carried out with a polyclonal antibody raised against choline acetyltransferase (ChAT). The cholinergic neuropil was not uniformly distributed in the striatum, and especially in the caudate nucleus ChAT-poor zones corresponding to acetylcholinesterase (AChE)-poor striosomes were identified. Striosomal organization of ChAT-positive neuropil was also detected in striatal tissue from patients who had suffered parkinsonian and choreic disorders.

Original language	English
Pages (from-to)	145-150
Number of pages	6
Journal	Neuroscience Letters
Volume	96
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(89)90048-7
State	Published - Jan 16 1989

Bibliographical note

Funding Information:
We thank Drs. J.J. Hauw, F. Javoy-Agid and P. Cervera for their help in the tissue preparation, Drs. G. Corkidi and J.C. Bisconte for their help in image analysis and H.F. Hall who is responsible for the photography. This work was supported by the Tourette Syndrome Association, NINCDS grant IR01 NS25529, Foundation Simone and Cino del Duca, United Parkinson's Disease Foundation, the Seaver Institute, NIH grant AG 05893 and INSERM. E.C. Hirsch is a fellow of the Fondation pour la Recherche Medicale.

Keywords

Acetylcholine
Choline acetyltransferase
Human
Immunocytochemistry
Striatum
Striosome

ASJC Scopus subject areas

General Neuroscience

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title = "Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum",

abstract = "Cholinergic neuropil and cell bodies were identified in the human striatum by immunohistochemistry carried out with a polyclonal antibody raised against choline acetyltransferase (ChAT). The cholinergic neuropil was not uniformly distributed in the striatum, and especially in the caudate nucleus ChAT-poor zones corresponding to acetylcholinesterase (AChE)-poor striosomes were identified. Striosomal organization of ChAT-positive neuropil was also detected in striatal tissue from patients who had suffered parkinsonian and choreic disorders.",

keywords = "Acetylcholine, Choline acetyltransferase, Human, Immunocytochemistry, Striatum, Striosome",

author = "Hirsch, {Etienne C.} and Graybiel, {Ann M.} and Hersh, {Louis B.} and Charles Duyckaerts and Yves Agid",

note = "Funding Information: We thank Drs. J.J. Hauw, F. Javoy-Agid and P. Cervera for their help in the tissue preparation, Drs. G. Corkidi and J.C. Bisconte for their help in image analysis and H.F. Hall who is responsible for the photography. This work was supported by the Tourette Syndrome Association, NINCDS grant IR01 NS25529, Foundation Simone and Cino del Duca, United Parkinson's Disease Foundation, the Seaver Institute, NIH grant AG 05893 and INSERM. E.C. Hirsch is a fellow of the Fondation pour la Recherche Medicale.",

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AU - Hirsch, Etienne C.

AU - Graybiel, Ann M.

AU - Hersh, Louis B.

AU - Duyckaerts, Charles

AU - Agid, Yves

N1 - Funding Information: We thank Drs. J.J. Hauw, F. Javoy-Agid and P. Cervera for their help in the tissue preparation, Drs. G. Corkidi and J.C. Bisconte for their help in image analysis and H.F. Hall who is responsible for the photography. This work was supported by the Tourette Syndrome Association, NINCDS grant IR01 NS25529, Foundation Simone and Cino del Duca, United Parkinson's Disease Foundation, the Seaver Institute, NIH grant AG 05893 and INSERM. E.C. Hirsch is a fellow of the Fondation pour la Recherche Medicale.

PY - 1989/1/16

Y1 - 1989/1/16

N2 - Cholinergic neuropil and cell bodies were identified in the human striatum by immunohistochemistry carried out with a polyclonal antibody raised against choline acetyltransferase (ChAT). The cholinergic neuropil was not uniformly distributed in the striatum, and especially in the caudate nucleus ChAT-poor zones corresponding to acetylcholinesterase (AChE)-poor striosomes were identified. Striosomal organization of ChAT-positive neuropil was also detected in striatal tissue from patients who had suffered parkinsonian and choreic disorders.

AB - Cholinergic neuropil and cell bodies were identified in the human striatum by immunohistochemistry carried out with a polyclonal antibody raised against choline acetyltransferase (ChAT). The cholinergic neuropil was not uniformly distributed in the striatum, and especially in the caudate nucleus ChAT-poor zones corresponding to acetylcholinesterase (AChE)-poor striosomes were identified. Striosomal organization of ChAT-positive neuropil was also detected in striatal tissue from patients who had suffered parkinsonian and choreic disorders.

KW - Acetylcholine

KW - Choline acetyltransferase

KW - Human

KW - Immunocytochemistry

KW - Striatum

KW - Striosome

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JO - Neuroscience Letters

JF - Neuroscience Letters

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Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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