Stroke: Understanding the differences between males and females

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Stroke is a significant cause of death and long-term disability in the USA. The incidence, mortality, and outcomes of stroke are significantly different between men and women. As with many diseases that affect men and women differently, an understanding on the reasons underlying those differences is critical to effective diagnosis and treatment. This review will examine the sex differences in stroke in both humans and animal models of stroke and review what is known about potential mechanisms underlying these differences. It is clear that there is a complex interaction between hormonal, genetic, and unknown factors at play in generating the sex differences in stroke.

Original languageEnglish
Pages (from-to)595-600
Number of pages6
JournalPflugers Archiv European Journal of Physiology
Issue number5
StatePublished - May 2013


  • Epigenetics
  • Estrogen
  • Gender
  • Progesterone
  • Stroke
  • Testosterone

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)


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